Evidence map›Paper›PMID 34072085›Full record

ArticleInternational journal of molecular sciences2021

Direct and Indirect Biomimetic Peptide Modification of Alginate: Efficiency, Side Reactions, and Cell Response.

Anna Golunova, Nadiia Velychkivska, Zuzana Mikšovská, Václav Chochola, Josef Jaroš, Aleš Hampl, Ognen Pop-Georgievski, Vladimír Proks

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Special Issue "Peptides for Health Benefits 2021".International journal of molecular sciences · 2024
    Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Anna GolunovaInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovsky Sq. 2, 16206 Prague, Czech Republic.ORCID 0000-0001-8364-3770
Nadiia VelychkivskaInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovsky Sq. 2, 16206 Prague, Czech Republic.ORCID 0000-0002-4950-1071
Zuzana MikšovskáInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovsky Sq. 2, 16206 Prague, Czech Republic.
Václav ChocholaDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 3, 62500 Brno, Czech Republic.
Josef JarošDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 3, 62500 Brno, Czech Republic.
Aleš HamplDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 3, 62500 Brno, Czech Republic.
Ognen Pop-GeorgievskiInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovsky Sq. 2, 16206 Prague, Czech Republic.ORCID 0000-0001-7938-9271
Vladimír ProksInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovsky Sq. 2, 16206 Prague, Czech Republic.ORCID 0000-0001-7368-7120
Czech Academy of Sciences, Institute of Macromolecular Chemistry · CZMasaryk University · CZ

Funding

Brno City Municipality - Brno Ph.D. Talent 2018 and European Regional Development Fund CZ.02.1.01/0.0/0.0/16_026/0008451Grantová Agentura České Republiky 18-05510SGrantová Agentura České Republiky 20-07313SMasarykova Univerzita MUNI/A/1689/2020
6 · The paper itself

Abstract

In the fast-developing field of tissue engineering there is a constant demand for new materials as scaffolds for cell seeding, which can better mimic a natural extracellular matrix as well as control cell behavior. Among other materials, polysaccharides are widely used for this purpose. One of the main candidates for scaffold fabrication is alginate. However, it lacks sites for cell adhesion. That is why one of the steps toward the development of suitable scaffolds for cells is the introduction of the biofunctionality to the alginate structure. In this work we focused on bone-sialoprotein derived peptide (TYRAY) conjugation to the molecule of alginate. Here the comparison study on four different approaches of peptide conjugation was performed including traditional and novel modification methods, based on 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide/

Indexed as

BiomimeticsTissue EngineeringTissue ScaffoldsAlginatesAminesCell AdhesionCell Culture TechniquesCell LineCell SurvivalClick ChemistryMagnetic Resonance SpectroscopyMolecular StructurePeptidesAlginatesAminesPeptidesadhesion-promoting peptidealginatecell adhesionhESCNMRpolysaccharide modificationXPS

Identifiers

PMID34072085
PMCPMC8198284
OpenAlexW3165326837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.