ArticleAntioxidants (Basel, Switzerland)2021
N-acetyl-L-cysteine Improves the Developmental Competence of Bovine Oocytes and Embryos Cultured In Vitro by Attenuating Oxidative Damage and Apoptosis.
Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- Advances in bovine oocyte in vitro maturation: mechanisms and strategies.Veterinary research communications · 2026Review
- Effects of Vitamin C, Rosmarinic Acid, or Quercetin on Fertilisation-Related Gene Expression in Porcine Cumulus-Oocyte Complexes During In Vitro Maturation.International journal of molecular sciences · 2026Article
- Meloxicam Alleviates Oxidative Stress Through Nrf2/HO-1 Activation in Bovine Endometrial Epithelial Cells.Veterinary sciences · 2025Article
- Environmental Stress-Induced Alterations in Embryo Developmental Morphokinetics.Journal of xenobiotics · 2024Review
- Evaluation of conical 9 well dish on bovine oocyte maturation and subsequent embryonic development.Journal of animal science and technology · 2024Article
- An Overview of Reactive Oxygen Species Damage Occurring during In Vitro Bovine Oocyte and Embryo Development and the Efficacy of Antioxidant Use to Limit These Adverse Effects.Animals : an open access journal from MDPI · 2024Review
- The Impact of Follicular Fluid Oxidative Stress Levels on the Outcomes of Assisted Reproductive Therapy.Antioxidants (Basel, Switzerland) · 2023Review
- Effects of N-acetylcysteine on Growth, Viability, and Ultrastructure of In Vitro Cultured Bovine Secondary Follicles.Animals : an open access journal from MDPI · 2022Article
- Effects of N Acetylcysteine on the Expression of Genes Associated with Reproductive Performance in the Goat Uterus during Early Gestation.Animals : an open access journal from MDPI · 2022Article
- Effect of Oxidative Stress on Reproduction and Development.Antioxidants (Basel, Switzerland) · 2022Article
- Role of N-acetylcysteine treatment in women with advanced age undergoing IVF/ICSI cycles: A prospective study.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Oxidative stress has been suggested to negatively affect oocyte and embryo quality and developmental competence, resulting in failure to reach full term. In this study, we investigated the effect of N-acetyl-L-cysteine (NAC), a cell-permeating antioxidant, on developmental competence and the quality of oocytes and embryos upon supplementation (0.1-10 mM) in maturation and culture medium in vitro using slaughterhouse-derived oocytes and embryos. The results show that treating oocytes with 1.0 mM NAC for 8 h during in vitro maturation attenuated the intracellular reactive oxygen species (ROS) (
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Registered trials
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