ReviewCells2021
Central vs. Peripheral Action of Thyroid Hormone in Adaptive Thermogenesis: A Burning Topic.
Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Ambient Developmental Temperatures and Maternal Thyroid Supply Promote Early Life Diversification in Salmonids.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2026Article
- Thyroid-metabolic interactions in pediatric epilepsy: insights from central sensitivity indices and peripheral hormone markers.European journal of pediatrics · 2026Article
- Diet's rapid effects on the thyroid gland challenge unidirectional assumptions about hypothyroidism and energy balance.The Journal of clinical investigation · 2026Article
- The complexity of the relationship between thyroid disease and body weight.Nature reviews. Endocrinology · 2026Review
- Adipocyte RNA-binding protein CELF1 promotes beiging of white fat through stabilizing Dio2 mRNA.Nature communications · 2025Article
- Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management-A State-of-the-Art Narrative Review.International journal of molecular sciences · 2024Review
- Adaptive Induction of Nonshivering Thermogenesis in Muscle Rather Than Brown Fat Could Counteract Obesity.Physiological research · 2024Review
- Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets.Signal transduction and targeted therapy · 2024Review
- The ecological function of thyroid hormones.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Temperature Differences Between Controlled Primary Hypothyroidism and Healthy Patients: An Exploratory Study.Journal of the Endocrine Society · 2024Article
- Physical exercise for a healthy pregnancy: the role of placentokines and exerkines.The journal of physiological sciences : JPS · 2023Review
- Comparative analysis of thyroid hormone systems in rodents with subterranean lifestyle.Scientific reports · 2023Article
- Strategies for Hypothermia Compensation in Altricial and Precocial Newborn Mammals and Their Monitoring by Infrared Thermography.Veterinary sciences · 2022Review
- The Role of Thyroid Hormones on Skeletal Muscle Thermogenesis.Metabolites · 2022Review
- Article
- Possible roles of exercise and apelin against pregnancy complications.Frontiers in endocrinology · 2022Review
- Article
- Sex Dimorphic Responses of the Hypothalamus-Pituitary-Thyroid Axis to Energy Demands and Stress.Frontiers in endocrinology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid hormones (TH) contribute to the control of adaptive thermogenesis, which is associated with both higher energy expenditure and lower body mass index. While it was clearly established that TH act directly in the target tissues to fulfill its metabolic activities, some studies have rather suggested that TH act in the hypothalamus to control these processes. This paradigm shift has subjected the topic to intense debates. This review aims to recapitulate how TH control adaptive thermogenesis and to what extent the brain is involved in this process. This is of crucial importance for the design of new pharmacological agents that would take advantage of the TH metabolic properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.