ArticleBrain sciences2021
Low-Intensity Focused Ultrasound-Mediated Attenuation of Acute Seizure Activity Based on EEG Brain Functional Connectivity.
Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Focused ultrasound for treatment of epilepsy: a systematic review and meta-analysis of preclinical and clinical studies.Neurosurgical review · 2024Pooled it
- GCaMP fiber photometry reveals mechanistic insights into focused ultrasound neuromodulation in acute seizures.NPJ acoustics · 2026Article
- Transcranial Focused Ultrasound Stimulation Targeting White Matter Inhibits Seizures in a Rat Model of Epilepsy.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Lead-free dual-frequency ultrasound implants for wireless, biphasic deep brain stimulation.Nature communications · 2024Article
- Excitatory-inhibitory modulation of transcranial focus ultrasound stimulation on human motor cortex.CNS neuroscience & therapeutics · 2023Article
- MR-Guided Focused Ultrasound for Refractory Epilepsy: Where Are We Now?Journal of clinical medicine · 2023Article
- Low-Intensity Pulsed Ultrasound Neuromodulation of a Rodent's Spinal Cord Suppresses Motor Evoked Potentials.IEEE transactions on bio-medical engineering · 2023Article
- Development of EEG connectivity from preschool to school-age children.Frontiers in neuroscience · 2023Article
- Transcranial low-intensity ultrasound stimulation for treating central nervous system disorders: A promising therapeutic application.Frontiers in neurology · 2023Review
- Ultrasonic therapies for seizures and drug-resistant epilepsy.Frontiers in neurology · 2023Review
- Low-Intensity Focused Ultrasound Neuromodulation for Stroke Recovery: A Novel Deep Brain Stimulation Approach for Neurorehabilitation?IEEE open journal of engineering in medicine and biology · 2023Article
- Positive Effect of α-Asaronol on the Incidence of Post-Stroke Epilepsy for Rat with Cerebral Ischemia-Reperfusion Injury.Molecules (Basel, Switzerland) · 2022Article
- Recent Advances in the Use of Focused Ultrasound as a Treatment for Epilepsy.Frontiers in neuroscience · 2022Review
- Article
- Different Modes of Low-Frequency Focused Ultrasound-Mediated Attenuation of Epilepsy Based on the Topological Theory.Micromachines · 2021Article
- Transcranial Focused Ultrasound Neuromodulation: A Review of the Excitatory and Inhibitory Effects on Brain Activity in Human and Animals.Frontiers in human neuroscience · 2021Review
- Transcranial low-intensity pulsed ultrasound in neurological disorders: mechanisms, therapeutic applications, and translational challenges.Frontiers in neurologyReview
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
(1) Background: Ultrasound has been used for noninvasive stimulation and is a promising technique for treating neurological diseases. Epilepsy is a common neurological disorder, that is attributed to uncontrollable abnormal neuronal hyperexcitability. Abnormal synchronized activities can be observed across multiple brain regions during a seizure. (2) Methods: we used low-intensity focused ultrasound (LIFU) to sonicate the brains of epileptic rats, analyzed the EEG functional brain network to explore the effect of LIFU on the epileptic brain network, and continued to explore the mechanism of ultrasound neuromodulation. LIFU was used in the hippocampus of epileptic rats in which a seizure was induced by kainic acid. (3) Results: By comparing the brain network characteristics before and after sonication, we found that LIFU significantly impacted the functional brain network, especially in the low-frequency band. The brain network connection strength across multiple brain regions significantly decreased after sonication compared to the connection strength in the control group. The brain network indicators (the path length, clustering coefficient, small-worldness, local efficiency and global efficiency) all changed significantly in the low-frequency. (4) Conclusions: These results revealed that LIFU could reduce the network connections of epilepsy circuits and change the structure of the brain network at the whole-brain level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.