Evidence map›Paper›PMID 34071946›Full record

ArticleViruses2021

Prevalence of Linda Virus Neutralizing Antibodies in the Austrian Pig Population.

Alexandra Kiesler, Jakob Plankensteiner, Lukas Schwarz, Christiane Riedel, Kerstin Seitz, Marlene Mötz, Andrea Ladinig, Benjamin Lamp, Till Rümenapf

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Alexandra KieslerDepartment for Pathobiology, Institute of Virology, University of Veterinary Medicine, Veterinaerplatz 1, 1210 Vienna, Austria.ORCID 0000-0001-8840-033X
Jakob PlankensteinerDepartment for Pathobiology, Institute of Virology, University of Veterinary Medicine, Veterinaerplatz 1, 1210 Vienna, Austria.
Lukas SchwarzDepartment for Farm Animals and Veterinary Public Health, University Clinic for Swine, University of Veterinary Medicine, Veterinaerplatz 1, 1210 Vienna, Austria.ORCID 0000-0002-4716-4913
Christiane RiedelDepartment for Pathobiology, Institute of Virology, University of Veterinary Medicine, Veterinaerplatz 1, 1210 Vienna, Austria.ORCID 0000-0002-4349-996X
Kerstin SeitzDepartment for Pathobiology, Institute of Virology, University of Veterinary Medicine, Veterinaerplatz 1, 1210 Vienna, Austria.ORCID 0000-0003-2852-5047
Marlene MötzDepartment for Pathobiology, Institute of Virology, University of Veterinary Medicine, Veterinaerplatz 1, 1210 Vienna, Austria.
Andrea LadinigDepartment for Farm Animals and Veterinary Public Health, University Clinic for Swine, University of Veterinary Medicine, Veterinaerplatz 1, 1210 Vienna, Austria.
Benjamin LampInstitute of Virology, Faculty of Veterinary Medicine, Justus-Liebig-University Giessen, Schubertstrasse 81, 35392 Giessen, Germany.ORCID 0000-0002-9668-1896
Till RümenapfDepartment for Pathobiology, Institute of Virology, University of Veterinary Medicine, Veterinaerplatz 1, 1210 Vienna, Austria.
University of Veterinary Medicine Vienna · ATJustus-Liebig-Universität Gießen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel pestivirus species, termed Lateral-shaking Inducing Neuro-Degenerative Agent virus (LindaV), was discovered in a piglet-producing farm in Austria in 2015 related to severe congenital tremor cases. Since the initial outbreak LindaV has not been found anywhere else. In this study, we determined the seroprevalence of LindaV infections in the domestic pig population of Austria. A fluorophore labeled infectious cDNA clone of LindaV (mCherry-LindaV) was generated and used in serum virus neutralization (SVN) assays for the detection of LindaV specific neutralizing antibodies in porcine serum samples. In total, 637 sera from sows and gilts from five federal states of Austria, collected between the years 2015 and 2020, were analyzed. We identified a single serum showing a high neutralizing antibody titer, that originated from a farm (Farm S2) in the proximity of the initially affected farm. The analysis of 57 additional sera from Farm S2 revealed a wider spread of LindaV in this pig herd. Furthermore, a second LindaV strain originating from this farm could be isolated in cell culture and was further characterized at the genetic level. Possible transmission routes and virus reservoir hosts of this emerging porcine virus need to be addressed in future studies.

Indexed as

AnimalsAntibodies, NeutralizingAntibodies, ViralAustriaFemaleMalePestivirusPestivirus InfectionsPrevalenceSeroepidemiologic StudiesSus scrofaSwineSwine DiseasesAntibodies, NeutralizingAntibodies, ViralLinda virusnovel Linda virus strainpestivirusesseroprevalenceserum virus neutralization assay

Identifiers

PMID34071946
PMCPMC8229103
OpenAlexW3165435421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.