Evidence map›Paper›PMID 34071903›Full record

ReviewAntioxidants (Basel, Switzerland)2021

Natural Antioxidant Application on Fat Accumulation: Preclinical Evidence.

Proshanta Roy, Daniele Tomassoni, Enea Traini, Ilenia Martinelli, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Francesco Amenta, Seyed Khosrow Tayebati

Open access · goldAbstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Purple corn cob (Journal of advanced veterinary and animal research · 2025
    Article
  6. Article
  7. Review
  8. SYNBIOMicroorganisms · 2023
    Article
  9. Article
  10. Article
  11. Supplementation withInternational journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Proshanta RoySchool of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy.
Daniele TomassoniSchool of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0001-9062-3305
Enea TrainiSchool of Pharmacy, University of Camerino, 62032 Camerino, Italy.
Ilenia MartinelliSchool of Pharmacy, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0002-7702-7784
Maria Vittoria Micioni Di BonaventuraSchool of Pharmacy, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0002-8044-1206
Carlo CifaniSchool of Pharmacy, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0001-6180-828X
Francesco AmentaSchool of Pharmacy, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0002-0555-1034
Seyed Khosrow TayebatiSchool of Pharmacy, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0002-7219-6917
Università di Camerino · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity represents one of the most important challenges in the contemporary world that must be overcome. Different pathological consequences of these physical conditions have been studied for more than 30 years. The most nagging effects were found early in the cardiovascular system. However, later, its negative impact was also investigated in several other organs. Damage at cellular structures due to overexpression of reactive oxygen species together with mechanisms that cause under-production of antioxidants leads to the development of obesity-related complications. In this view, the negative results of oxidant molecules due to obesity were studied in various districts of the body. In the last ten years, scientific literature has reported reasonable evidence regarding natural and synthetic compounds' supplementation, which showed benefits in reducing oxidative stress and inflammatory processes in animal models of obesity. This article attempts to clarify the role of oxidative stress due to obesity and the opposing role of antioxidants to counter it, reported in preclinical studies. This analysis aims to clear-up different mechanisms that lead to the build-up of pro-oxidants during obesity and how various molecules of different origins hinder this phenomenon, behaving as antioxidants.

Indexed as

antioxidantinflammationobesitypreclinical studies

Identifiers

PMID34071903
PMCPMC8227384
OpenAlexW3165473272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.