Evidence map›Paper›PMID 34071869›Full record

ReviewCancers2021

Current Evidence of the Role of the Myokine Irisin in Cancer.

Evangelia Tsiani, Nicole Tsakiridis, Rozalia Kouvelioti, Alina Jaglanian, Panagiota Klentrou

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07048847 (The Effect of Supervised Aerobic Exercise on Adipokine and Myokine Biomarkers in Patients With Cancer During Systemic Chemotherapy), which is not on this map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07048847 completednot on this mapstarted 2022, after this paper: background citation

The Effect of Supervised Aerobic Exercise on Adipokine and Myokine Biomarkers in Patients With Cancer During Systemic Chemotherapy

TypeobservationalSponsorIzmir Bakircay UniversityRan2022 to 2023Enrolled32ConditionsBreast Cancer, Colon Cancer, Chemotherapy EffectArmsExercise
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Evangelia TsianiDepartment of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada.
Nicole TsakiridisDepartment of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada.
Rozalia KouveliotiDepartment of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada.
Alina JaglanianDepartment of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada.ORCID 0000-0001-6946-3108
Panagiota KlentrouCentre for Bone and Muscle Health, Brock University, St. Catharines, ON L2S 3A1, Canada.ORCID 0000-0003-0328-5198

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is a disease associated with extreme human suffering, a huge economic cost to health systems, and is the second leading cause of death worldwide. Regular physical activity is associated with many health benefits, including reduced cancer risk. In the past two decades, exercising/contracting skeletal muscles have been found to secrete a wide range of biologically active proteins, named myokines. Myokines are delivered, via the circulation, to different cells/tissues, bind to their specific receptors and initiate signaling cascades mediating the health benefits of exercise. The present review summarizes the existing evidence of the role of the myokine irisin in cancer. In vitro studies have shown that the treatment of various cancer cells with irisin resulted in the inhibition of cell proliferation, survival, migration/ invasion and induced apoptosis by affecting key proliferative and antiapoptotic signaling pathways. However, the effects of irisin in humans remains unclear. Although the majority of the existing studies have found reduced serum irisin levels in cancer patients, a few studies have shown the opposite. Similarly, the majority of studies have found increased levels of irisin in cancer tissues, with a few studies showing the opposite trend. Clearly, further investigations are required to determine the exact role of irisin in cancer.

Indexed as

cancercontractionexercisehealth benefitsin vitroin vivoirisinmusclemyokines

Identifiers

PMID34071869
PMCPMC8199282

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.