ReviewMolecules (Basel, Switzerland)2021
Amino Acids as the Potential Co-Former for Co-Crystal Development: A Review.
Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 65 citations in OpenAlex.
- Amino Acids as Sustainable Alternatives to Allergenic Sulfur Vulcanization Accelerators for Carbon Black-Filled Nitrile Rubber.Molecules (Basel, Switzerland) · 2026Article
- From triggers to interfaces: polymer-stabilized nano-co-crystals for robust mesalazine delivery in UC.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026Review
- Enantiomer-Specific Nucleation Phase Selection under Nonequilibrium Optical Trapping.The journal of physical chemistry letters · 2026Article
- Development and optimization of asiaticoside co-crystal-loaded transdermal patch for topical therapy.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Recent Advances and Future Directions in 5-Fluorouracil Drug Delivery: A Comprehensive Review.Current topics in medicinal chemistry · 2026Review
- First Crystal Structure of an Aspartame Cocrystal.Crystal growth & design · 2025Article
- Impact of the Coformer Carbon-Chain Length on the Properties of Haloperidol Pharmaceutical Salts.Crystal growth & design · 2025Article
- Carrier-free nanoparticles-new strategy of improving druggability of natural products.Journal of nanobiotechnology · 2025Review
- Optimization of physicochemical properties of theophylline by forming cocrystals with amino acids.RSC advances · 2024Article
- Article
- Multicomponent Amorphous Solid Forms of Telmisartan: Insights into Mechanochemical Activation and Physicochemical Attributes.AAPS PharmSciTech · 2024Article
- Article
- Amorphous Solid Forms of Ranolazine and Tryptophan and Their Relaxation to Metastable Polymorphs.Crystal growth & design · 2023Article
- A Novel Curcumin Arginine Salt: A Solution for Poor Solubility and Potential Anticancer Activities.Molecules (Basel, Switzerland) · 2022Article
- Non-Covalent Reactions Supporting Antiviral Development.Molecules (Basel, Switzerland) · 2022Review
- Recent Advances on the Biological Study of Pharmaceutical Cocrystals.AAPS PharmSciTech · 2022Review
- Synthesis, characterization, and thermal and computational investigations of the L-histidine bis(fluoride) crystal.Journal of molecular modeling · 2022Article
- Vibrational Spectroscopy of Homo- and Heterochiral Amino Acid Dimers: Conformational Landscapes.Molecules (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Co-crystals are one of the most popular ways to modify the physicochemical properties of active pharmaceutical ingredients (API) without changing pharmacological activity through non-covalent interactions with one or more co-formers. A "green method" has recently prompted many researchers to develop solvent-free techniques or minimize solvents for arranging the eco-friendlier process of co-crystallization. Researchers have also been looking for less-risk co-formers that produce the desired API's physicochemical properties. This review purposed to collect the report studies of amino acids as the safe co-former and explored their advantages. Structurally, amino acids are promising co-former candidates as they have functional groups that can form hydrogen bonds and increase stability through zwitterionic moieties, which support strong interactions. The co-crystals and deep eutectic solvent yielded from this natural compound have been proven to improve pharmaceutical performance. For example, l-glutamine could reduce the side effects of mesalamine through an acid-base stabilizing effect in the gastrointestinal fluid. In addition, some amino acids, especially l-proline, enhances API's solubility and absorption in its natural deep eutectic solvent and co-crystals systems. Moreover, some ionic co-crystals of amino acids have also been designed to increase chiral resolution. Therefore, amino acids are safe potential co-formers, which are suitable for improving the physicochemical properties of API and prospective to be developed further in the dosage formula and solid-state syntheses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.