Evidence map›Paper›PMID 34071681›Full record

ArticleJournal of clinical medicine2021

Mitochondrial DNA Instability Is Common in HIV-Exposed Uninfected Newborns.

Audrey Monnin, Valérie Desquiret-Dumas, Nicolas Méda, David Goudenège, Céline Bris, Chipepo Kankasa, Mandisa Singata-Madliki, Thorkild Tylleskar, Vincent Procaccio, Nicolas Nagot and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 5 countries.

Audrey MonninPathogenesis and Control of Chronic and Emerging Infections, INSERM, Etablissement Français du Sang, University of Montpellier, University of the Antilles, 34393 Montpellier, France.ORCID 0000-0002-0034-8918
Valérie Desquiret-DumasDepartment of Biochemistry and Genetics, University Hospital of Angers, 49933 Angers, France.
Nicolas MédaCentre MURAZ, Box390 Bobo-Dioulasso, Burkina Faso.
David GoudenègeDepartment of Biochemistry and Genetics, University Hospital of Angers, 49933 Angers, France.
Céline BrisDepartment of Biochemistry and Genetics, University Hospital of Angers, 49933 Angers, France.
Chipepo KankasaDepartment of Paediatrics and Child Health, University Teaching Hospital, Lusaka P.O. Box 50110, Zambia.
Mandisa Singata-MadlikiEffective Care Research Unit, University of Fort Hare, East London 5201, South Africa.
Thorkild TylleskarCentre for International Health, University of Bergen, 5020 Bergen, Norway.
Vincent ProcaccioDepartment of Biochemistry and Genetics, University Hospital of Angers, 49933 Angers, France.
Nicolas NagotPathogenesis and Control of Chronic and Emerging Infections, INSERM, Etablissement Français du Sang, University of Montpellier, University of the Antilles, 34393 Montpellier, France.
Philippe Van de PerrePathogenesis and Control of Chronic and Emerging Infections, INSERM, Etablissement Français du Sang, University of Montpellier, University of the Antilles, 34393 Montpellier, France.
Pascal ReynierDepartment of Biochemistry and Genetics, University Hospital of Angers, 49933 Angers, France.
Jean-Pierre MolèsPathogenesis and Control of Chronic and Emerging Infections, INSERM, Etablissement Français du Sang, University of Montpellier, University of the Antilles, 34393 Montpellier, France.ORCID 0000-0002-6863-6350
Centre National de la Recherche Scientifique · FRInserm · FRCentre Muraz · BFUniversity of Bergen · NOUniversity of Fort Hare · ZAUniversity Teaching Hospital · ZM

Funding

Agence Nationale de Recherches sur le Sida et les Hépatites Virales ANRS12174-B90Agence Nationale de Recherches sur le Sida et les Hépatites Virales ANRS#12274European and Developing Countries Clinical Trials Partnership #CT.2006.33020.004Research Council of Norway # 183600
6 · The paper itself

Abstract

Worldwide, one million HIV-exposed uninfected (HEU) children are born yearly, and chronic health impairments have been reported in these children. Mitochondrial DNA (mtDNA) instability and altered mtDNA content have been evidenced in these children, but an exhaustive characterization of altered mitochondrial genomes has never been reported. We applied deep mtDNA sequencing coupled to the deletion identification algorithm eKLIPse to the blood of HEU neonates (

Indexed as

ARVbirthgenomic alterationsHIVmitochondriapediatric

Identifiers

PMID34071681
PMCPMC8197798
OpenAlexW3165842771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.