Evidence map›Paper›PMID 34071673›Full record

ArticleMolecules (Basel, Switzerland)2021

Effect of the Addition of Alginate and/or Tetracycline on Brushite Cement Properties.

Claudia Morilla, Elianis Perdomo, Ana Karla Hernández, Ramcy Regalado, Amisel Almirall, Gastón Fuentes, Yaima Campos Mora, Timo Schomann, Alan Chan, Luis J Cruz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Claudia MorillaBiomaterials Center, University of Havana, La Habana 10400, Cuba.
Elianis PerdomoFaculty of Automatic and Biomedical Engineering, Technological University of Havana, La Habana 11300, Cuba.
Ana Karla HernándezBiomaterials Center, University of Havana, La Habana 10400, Cuba.
Ramcy RegaladoBiomaterials Center, University of Havana, La Habana 10400, Cuba.
Amisel AlmirallBiomaterials Center, University of Havana, La Habana 10400, Cuba.
Gastón FuentesBiomaterials Center, University of Havana, La Habana 10400, Cuba.ORCID 0000-0002-9930-6063
Yaima Campos MoraBiomaterials Center, University of Havana, La Habana 10400, Cuba.
Timo SchomannTranslational Nanobiomaterials and Imaging Group, Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-0948-6209
Alan ChanPercuros B.V., 2333 CL Leiden, The Netherlands.
Luis J CruzTranslational Nanobiomaterials and Imaging Group, Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
University of Havana · CULeiden University Medical Center · NLPercuros (Netherlands) · NL

Funding

Erasmus+ 2015-1-NL01-KA 107-008639H2020 Marie Skłodowska-Curie Actions RISE-2016 (734684-CHARMED)H2020 Marie Skłodowska-Curie Actions RISE (644373-PRISAR)H2020 Marie Skłodowska-Curie Actions RISE (777682-CANCER)H2020 WIDESPREAD 05-2017-Twinning (807281-ACORN)H2020 WIDESPREAD 2018-03 (852985-SIMICA)MSCA-ITN-2015-ETN (675743-ISPIC), 861190 (PAVE), 857894 (CAST), 859908 (NOVA-MRI); 872860 (PRISAR2)VIDI 723.012.110
6 · The paper itself

Abstract

Calcium phosphate cements have the advantage that they can be prepared as a paste that sets in a few minutes and can be easily adapted to the shape of the bone defect, which facilitates its clinical application. In this research, six formulations of brushite (dicalcium phosphate dihydrated) cement were obtained and the effect of the addition of sodium alginate was analyzed, such as its capacity as a tetracycline release system. The samples that contain sodium alginate set in 4 or 5 min and showed a high percentage of injectability (93%). The cements exhibit compression resistance values between 1.6 and 2.6 MPa. The drug was released in a range between 12.6 and 13.2% after 7 days. The antimicrobial activity of all the cements containing antibiotics was proven. All samples reached values of cell viability above 70 percent. We also observed that the addition of the sodium alginate and tetracycline improved the cell viability.

Indexed as

3T3-L1 CellsAlginatesAnimalsAnti-Bacterial AgentsBiocompatible MaterialsBone CementsBone RegenerationCalcium PhosphatesCell ProliferationCell SurvivalCompressive StrengthHydrogen-Ion ConcentrationMiceMicroscopy, Electron, ScanningMicroscopy, Electron, TransmissionPressureAlginatesAnti-Bacterial AgentsBiocompatible MaterialsBone Cementscalcium phosphate, dibasic, dihydrateCalcium PhosphatesTetracyclinebrushitecalcium phosphate cementscell viabilitymechanical propertiesmicrobiological propertiesphysical-chemical properties

Identifiers

PMID34071673
PMCPMC8199332
OpenAlexW3164359255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.