Evidence map›Paper›PMID 34071649›Full record

ArticleBrain sciences2021

Selecting the Most Relevant Brain Regions to Classify Children with Developmental Dyslexia and Typical Readers by Using Complex Magnocellular Stimuli and Multiple Kernel Learning.

Sara Mascheretti, Denis Peruzzo, Chiara Andreola, Martina Villa, Tommaso Ciceri, Vittoria Trezzi, Cecilia Marino, Filippo Arrigoni

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Sara MascherettiChild Psychopathology Unit, Scientific Institute, IRCCS Eugenio Medea, 23842 Bosisio Parini, Italy.
Denis PeruzzoNeuroimaging Lab, Scientific Institute, IRCCS Eugenio Medea, 23842 Bosisio Parini, Italy.ORCID 0000-0002-9480-379X
Chiara AndreolaChild Psychopathology Unit, Scientific Institute, IRCCS Eugenio Medea, 23842 Bosisio Parini, Italy.ORCID 0000-0002-9388-2772
Martina VillaChild Psychopathology Unit, Scientific Institute, IRCCS Eugenio Medea, 23842 Bosisio Parini, Italy.ORCID 0000-0002-1776-5582
Tommaso CiceriNeuroimaging Lab, Scientific Institute, IRCCS Eugenio Medea, 23842 Bosisio Parini, Italy.
Vittoria TrezziChild Psychopathology Unit, Scientific Institute, IRCCS Eugenio Medea, 23842 Bosisio Parini, Italy.
Cecilia MarinoThe Division of Child and Youth Psychiatry at the Centre for Addiction and Mental Health (CAMH), Toronto, ON M6J 1H4, Canada.
Filippo ArrigoniNeuroimaging Lab, Scientific Institute, IRCCS Eugenio Medea, 23842 Bosisio Parini, Italy.ORCID 0000-0002-5508-1149
IRCCS Eugenio Medea · ITCentre for Addiction and Mental Health · CAUniversité Paris Cité · FR

Funding

Cinque per milleItalian Ministry of Health Grants Ricerca Corrente 2019Italian Ministry of Health Grants Ricerca Corrente 2020
6 · The paper itself

Abstract

Increasing evidence supports the presence of deficits in the visual magnocellular (M) system in developmental dyslexia (DD). The M system is related to the fronto-parietal attentional network. Previous neuroimaging studies have revealed reduced/absent activation within the visual M pathway in DD, but they have failed to characterize the extensive brain network activated by M stimuli. We performed a multivariate pattern analysis on a Region of Interest (ROI) level to differentiate between children with DD and age-matched typical readers (TRs) by combining full-field sinusoidal gratings, controlled for spatial and temporal frequencies and luminance contrast, and a coherent motion (CM) sensitivity task at 6%-CML6, 15%-CML15 and 40%-CML40. ROIs spanning the entire visual dorsal stream and ventral attention network (VAN) had higher discriminative weights and showed higher act1ivation in TRs than in children with DD. Of the two tasks, CM had the greatest weight when classifying TRs and children with DD in most of the ROIs spanning these streams. For the CML6, activation within the right superior parietal cortex positively correlated with reading skills. Our approach highlighted the dorsal stream and the VAN as highly discriminative areas between children with DD and TRs and allowed for a better characterization of the "dorsal stream vulnerability" underlying DD.

Indexed as

attentiondevelopmental dyslexiadorsal stream vulnerabilityfMRImultiple kernel learningvisual dorsal pathway

Identifiers

PMID34071649
PMCPMC8228080
OpenAlexW3165863251

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.