Evidence map›Paper›PMID 34071571›Full record

ArticlePharmaceutics2021

Anti-Inflammatory and Immunomodulatory Effects of the

Sarah Tomas-Hernandez, Jordi Blanco, Santiago Garcia-Vallvé, Gerard Pujadas, María José Ojeda-Montes, Aleix Gimeno, Lluís Arola, Luisa Minghetti, Raúl Beltrán-Debón, Miquel Mulero

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Foods (Basel, Switzerland) · 2025
    Article
  2. Extracts ofNutrition research and practice · 2023
    Article
  3. Review
  4. Review
  5. Article
  6. Antioxidants (Basel, Switzerland) · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Sarah Tomas-HernandezCheminformatics and Nutrition Group, Department of Biochemistry and Biotechnology, Campus Sescelades, Universitat Rovira i Virgili (URV), 43007 Tarragona, Catalonia, Spain.
Jordi BlancoPhysiology Unit, Laboratory of Toxicology and Environmental Health, Research in Neurobehavior and Health (NEUROLAB), School of Medicine, IISPV, Universitat Rovira i Virgili (URV), 43202 Tarragona, Catalonia, Spain.
Santiago Garcia-VallvéCheminformatics and Nutrition Group, Department of Biochemistry and Biotechnology, Campus Sescelades, Universitat Rovira i Virgili (URV), 43007 Tarragona, Catalonia, Spain.ORCID 0000-0002-0348-7497
Gerard PujadasCheminformatics and Nutrition Group, Department of Biochemistry and Biotechnology, Campus Sescelades, Universitat Rovira i Virgili (URV), 43007 Tarragona, Catalonia, Spain.ORCID 0000-0003-2598-8089
María José Ojeda-MontesCheminformatics and Nutrition Group, Department of Biochemistry and Biotechnology, Campus Sescelades, Universitat Rovira i Virgili (URV), 43007 Tarragona, Catalonia, Spain.
Aleix GimenoCheminformatics and Nutrition Group, Department of Biochemistry and Biotechnology, Campus Sescelades, Universitat Rovira i Virgili (URV), 43007 Tarragona, Catalonia, Spain.
Lluís ArolaNutrigenomics Research Group, Department of Biochemistry and Biotechnology, Campus Sescelades, Universitat Rovira i Virgili (URV), 43007 Tarragona, Catalonia, Spain.
Luisa MinghettiDepartment of Cell Biology and Neurosciences, Istituto Superiore di Sanità, 00161 Rome, Italy.
Raúl Beltrán-DebónMoBioFood Research Group, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, 43007 Tarragona, Catalonia, Spain.ORCID 0000-0001-9691-1906
Miquel MuleroNutrigenomics Research Group, Department of Biochemistry and Biotechnology, Campus Sescelades, Universitat Rovira i Virgili (URV), 43007 Tarragona, Catalonia, Spain.ORCID 0000-0003-2545-2065
Universitat Rovira i Virgili · ESInstitut de Recerca Biomèdica Catalunya Sud · ESInstitute for Research in Biomedicine · ESIstituto Superiore di Sanità · ITSIB Swiss Institute of Bioinformatics · CH

Funding

Generalitat de Catalunya 2015FI_B00655Universitat Rovira i Virgili 2012BPURVUniversitat Rovira i Virgili 2014PFR-URV-B2-67Universitat Rovira i Virgili 2015PFR-URV-B2-67
6 · The paper itself

Abstract

In response to foreign or endogenous stimuli, both microglia and astrocytes adopt an activated phenotype that promotes the release of pro-inflammatory mediators. This inflammatory mechanism, known as neuroinflammation, is essential in the defense against foreign invasion and in normal tissue repair; nevertheless, when constantly activated, this process can become detrimental through the release of neurotoxic factors that amplify underlying disease. In consequence, this study presents the anti-inflammatory and immunomodulatory properties of

Indexed as

astrocytesGrifola frondosaimmunomodulationJNKmicroglianatural compoundsneuro-inflammationNF-κBo-orsellinaldehydep38 kinase

Identifiers

PMID34071571
PMCPMC8229786
OpenAlexW3165079034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.