ReviewNutrients2021
Evidence-Based Recommendations for an Optimal Prenatal Supplement for Women in the U.S., Part Two: Minerals.
Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- The Role of Selenium During Gestation in the Development of Fetal Congenital Anomalies: A Systematic Review.Nutrients · 2026Pooled it
- Maternal serum zinc level is associated with risk of preeclampsia: A systematic review and meta-analysis.Frontiers in public health · 2022Pooled it
- A Multicountry Analysis of Maternal Selenium Status in Pregnancy and Lactation and Infant Birth Outcomes: Findings from the Women First Maternal Preconception Study.The Journal of nutrition · 2026Trial
- Serum Magnesium and Zinc Levels in Pregnant Women with Preeclampsia Compared to Healthy Controls: Case-Control Study.Biological trace element research · 2026Article
- Evolving Concepts in Gestational Iodine Requirements.Healthcare (Basel, Switzerland) · 2026Review
- Could excessive zinc supplementation during pregnancy cause menkes disease? A hypothesis worth investigating.Frontiers in pediatrics · 2026Review
- Article
- The effect of folic acid or multivitamin containing folic acid supplementation during pregnancy on enamel structure of deciduous teeth: an ultrastructural and microanalytical study.Head & face medicine · 2025Article
- A Comprehensive Review on Plant-Based Medications and Chemical Approaches for Autism Spectrum Disorders (ASDs) Psychopharmacotherapy.Indian journal of microbiology · 2025Article
- Fetal Growth Is Associated with Amniotic Fluid Antioxidant Capacity, Oxidative Stress, Minerals and Prenatal Supplementation: A Retrospective Study.Antioxidants (Basel, Switzerland) · 2025Article
- Effect of Dietary Magnesium on the Association Between Serum Uric Acid and Female Infertility.International journal of women's health · 2025Article
- Optimizing Pregnancy Outcomes: The Role of Gynecologists in Preconceptional Care in Italy.International journal of women's health · 2025Article
- Nutrition, Pregnancy, and Preexisting Diabetes: Exploring What Has Changed and What Remains the Same.Diabetes spectrum : a publication of the American Diabetes Association · 2025Article
- Epigenetic Genome Modifications during Pregnancy: The Impact of Essential Nutritional Supplements on DNA Methylation.Nutrients · 2024Review
- Micronutrients in early life and offspring metabolic health programming: a promising target for preventing non-communicable diseases.European journal of clinical nutrition · 2023Review
- Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World.Nutrients · 2023Article
- Selecting a dietary supplement with appropriate dosing for 6 key nutrients in pregnancy.The American journal of clinical nutrition · 2023Article
- Nutritional Composition and Antioxidant Activity ofPlants (Basel, Switzerland) · 2023Article
- Association between magnesium intake and the risk of anemia among adults in the United States.Frontiers in nutrition · 2023Article
- Gene-nutrient interactions that impact magnesium homeostasis increase risk for neural tube defects in mice exposed to dolutegravir.Frontiers in cell and developmental biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The levels of many essential minerals decrease during pregnancy if un-supplemented, including calcium, iron, magnesium, selenium, zinc, and possibly chromium and iodine. Sub-optimal intake of minerals from preconception through pregnancy increases the risk of many pregnancy complications and infant health problems. In the U.S., dietary intake of minerals is often below the Recommended Dietary Allowance (RDA), especially for iodine and magnesium, and 28% of women develop iron deficiency anemia during their third trimester. The goal of this paper is to propose evidence-based recommendations for the optimal level of prenatal supplementation for each mineral for most women in the United States. Overall, the evidence suggests that optimal mineral supplementation can significantly reduce a wide range of pregnancy complications (including anemia, gestational hypertension, gestational diabetes, hyperthyroidism, miscarriage, and pre-eclampsia) and infant health problems (including anemia, asthma/wheeze, autism, cerebral palsy, hypothyroidism, intellectual disability, low birth weight, neural tube defects, preterm birth, rickets, and wheeze). An evaluation of 180 commercial prenatal supplements found that they varied widely in mineral content, often contained only a subset of essential minerals, and the levels were often below our recommendations. Therefore, there is a need to establish recommendations on the optimal level of mineral supplementation during pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.