Evidence map›Paper›PMID 34071547›Full record

ArticleJournal of personalized medicine2021

Different Associations between Tonsil Microbiome, Chronic Tonsillitis, and Intermittent Hypoxemia among Obstructive Sleep Apnea Children of Different Weight Status: A Pilot Case-Control Study.

Hai-Hua Chuang, Jen-Fu Hsu, Li-Pang Chuang, Cheng-Hsun Chiu, Yen-Lin Huang, Hsueh-Yu Li, Ning-Hung Chen, Yu-Shu Huang, Chun-Wei Chuang, Chung-Guei Huang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 20 citations in OpenAlex.

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  17. Alterations of Gut Microbiome Composition and Function Pre- and Post-Adenotonsillectomy in Children with Obstructive Sleep Apnea.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Hai-Hua ChuangDepartment of Family Medicine, Chang Gung Memorial Hospital, Taipei Branch and Linkou Main Branch, Taoyuan 33305, Taiwan.ORCID 0000-0002-7394-4016
Jen-Fu HsuCollege of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0003-0798-5378
Li-Pang ChuangCollege of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0001-5466-8995
Cheng-Hsun ChiuCollege of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Yen-Lin HuangCollege of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Hsueh-Yu LiCollege of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Ning-Hung ChenCollege of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Yu-Shu HuangCollege of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0002-4015-5942
Chun-Wei ChuangDepartment of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan 33305, Taiwan.
Chung-Guei HuangDepartment of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan 33305, Taiwan.
Hsin-Chih LaiDepartment of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan 33305, Taiwan.
Li-Ang LeeCollege of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0001-8414-595X
Chang Gung University · TWChang Gung Memorial Hospital · TWNational Taipei University of Technology · TW

Funding

Chang Gung Medical Foundation 3C0661, 3C0662, 3C0663, and 3F1092
6 · The paper itself

Abstract

The tonsil microbiome is associated with chronic tonsillitis and obstructive sleep apnea (OSA) in children, and the gut microbiome is associated with host weight status. In this study, we hypothesized that weight status may be associated with clinical profiles and the tonsil microbiome in children with OSA. We prospectively enrolled 33 non-healthy-weight (cases) and 33 healthy-weight (controls) pediatric OSA patients matched by the proportion of chronic tonsillitis. Differences in the tonsil microbiome between the non-healthy-weight and healthy-weight subgroups and relationships between the tonsil microbiome and clinical variables were investigated. Non-healthy weight was associated with significant intermittent hypoxemia (oxygen desaturation index, mean blood saturation (SpO

Indexed as

childrenintermittent hypoxemiamicrobiomeobstructive sleep apneatonsilweight status

Identifiers

PMID34071547
PMCPMC8227284
OpenAlexW3165397004

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.