ReviewMolecules (Basel, Switzerland)2021
Deferoxamine B: A Natural, Excellent and Versatile Metal Chelator.
Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 143 citations in OpenAlex.
- Article
- Siderophore-metal complexes in Paraburkholderia phymatum: structure elucidation of phymabactin.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Data-driven optimization of siderophore fermentation byApplied and environmental microbiology · 2026Article
- Biocompatible Glycoconjugation Enables Sensitive In Vivo Cell Tracking by PET/CT.Journal of medicinal chemistry · 2026Article
- Development of a hemolysis filter system for the selective removal of free hemoglobin, haem and iron from blood envisaged for use in extracorporeal circuits.Scientific reports · 2026Article
- TheEuropean journal of nuclear medicine and molecular imaging · 2026Observational
- Synthesis and Evaluation of D8W, an Octadentate Desferrioxamine Analogue with Enhanced Water Solubility Designed forMolecular pharmaceutics · 2026Article
- Potent anticancer activity of phenolic-enriched extracts from endemic plants supported by in vitro pharmacological analyses and in silico molecular docking.Die Naturwissenschaften · 2026Article
- Biology of novel LpxC inhibitors forMicrobiology spectrum · 2026Article
- Size-Controlled Mesoporous Silica Nanoparticles via Template Nanoarchitectonics from a Deferoxamine Derivative for Enhanced Blood-Brain Barrier Permeability and Neuroprotective Chelation Therapy.ACS applied materials & interfaces · 2025Article
- Whole genome surveying and metabolomic profiling aided navigation of therapeutic plethora of Streptomyces melanogenes WPF1 isolated from Pinus patula rhizosphere.Bioresources and bioprocessing · 2025Article
- Transmetalation in Cancer Pharmacology.International journal of molecular sciences · 2025Review
- A Comprehensive Machine Learning Model for Metal-Ligand Binding Prediction: Applications in Chemistry and Biology.Journal of chemical information and modeling · 2025Article
- Bioproduction Optimization, Characterization, and Bioactivity of Extracellular Pigment Produced byInternational journal of molecular sciences · 2025Article
- Hydrogels in Heritage Conservation: A Comparative Evaluation on Composite Objects.Gels (Basel, Switzerland) · 2025Article
- Integrative Single-Cell Analysis Reveals Iron Overload-Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis-Associated Infertility.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Efficacy of Various Complexing Agents for Displacing Biologically Important Ligands from Eu(III) and Cm(III) Complexes in Artificial Body Fluids-An In Vitro Decorporation Study.International journal of molecular sciences · 2025Article
- Fluorescent Deferoxamine Complexes of Cu(II) and Zr(IV): Insights in the Development of Dual Imaging Probes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Harnessing the effect of iron deprivation to attenuate the growth of opportunistic pathogenAntimicrobial agents and chemotherapy · 2025Article
- Fimsbactin Siderophores From a South African Marine Sponge Symbiont, Marinomonas sp. PE14-40.Microbial biotechnology · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Deferoxamine B is an outstanding molecule which has been widely studied in the past decade for its ability to bind iron and many other metal ions. The versatility of this metal chelator makes it suitable for a number of medicinal and analytical applications, from the well-known iron chelation therapy to the most recent use in sensor devices. The three bidentate hydroxamic functional groups of deferoxamine B are the centerpiece of its metal binding ability, which allows the formation of stable complexes with many transition, lanthanoid and actinoid metal ions. In addition to the ferric ion, in fact, more than 20 different metal complexes of deferoxamine b have been characterized in terms of their chemical speciation in solution. In addition, the availability of a terminal amino group, most often not involved in complexation, opens the way to deferoxamine B modification and functionalization. This review aims to collect and summarize the available data concerning the complex-formation equilibria in solutions of deferoxamine B with different metal ions. A general overview of the progress of its applications over the past decade is also discussed, including the treatment of iron overload-associated diseases, its clinical use against cancer and neurodegenerative disorders and its role as a diagnostic tool.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.