Evidence map›Paper›PMID 34071459›Full record

ReviewFoods (Basel, Switzerland)2021

Searching for the Antioxidant, Anti-Inflammatory, and Neuroprotective Potential of Natural Food and Nutritional Supplements for Ocular Health in the Mediterranean Population.

Mar Valero-Vello, Cristina Peris-Martínez, José J García-Medina, Silvia M Sanz-González, Ana I Ramírez, José A Fernández-Albarral, David Galarreta-Mira, Vicente Zanón-Moreno, Ricardo P Casaroli-Marano, María D Pinazo-Duran

Open access · goldAbstract readReview
In one paragraph

Review in Foods (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
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  11. Nutritional and dietary clinical trials for Parkinson's disease: a narrative review.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
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  13. Combination ofInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Mar Valero-VelloOphthalmic Research Unit "Santiago Grisolía" Foundation for the Promotion of Health and Biomedical Research of Valencia FISABIO, 46017 Valencia, Spain.ORCID 0000-0001-6466-9377
Cristina Peris-MartínezOphthalmic Medical Center (FOM), Foundation for the Promotion of Health and Biomedical Research of Valencia (FISABIO), 46015 Valencia, Spain.ORCID 0000-0001-5992-5006
José J García-MedinaOphthalmic Research Unit "Santiago Grisolía" Foundation for the Promotion of Health and Biomedical Research of Valencia FISABIO, 46017 Valencia, Spain.ORCID 0000-0002-6245-7271
Silvia M Sanz-GonzálezOphthalmic Research Unit "Santiago Grisolía" Foundation for the Promotion of Health and Biomedical Research of Valencia FISABIO, 46017 Valencia, Spain.ORCID 0000-0002-9569-1451
Ana I RamírezSpanish Net of Ophthalmic Research "OFTARED" RD16/0008/0022, Institute of Health Carlos III, 28029 Madrid, Spain.ORCID 0000-0002-2656-4723
José A Fernández-AlbarralDepartment of Immunology, Ophthalmology and Otorrinolaringology, Institute of Ophthalmic Research "Ramón Castroviejo", Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0003-0399-7996
David Galarreta-MiraSpanish Net of Ophthalmic Research "OFTARED" RD16/0008/0022, Institute of Health Carlos III, 28029 Madrid, Spain.
Vicente Zanón-MorenoOphthalmic Research Unit "Santiago Grisolía" Foundation for the Promotion of Health and Biomedical Research of Valencia FISABIO, 46017 Valencia, Spain.ORCID 0000-0003-1179-1592
Ricardo P Casaroli-MaranoSpanish Net of Ophthalmic Research "OFTARED" RD16/0008/0022, Institute of Health Carlos III, 28029 Madrid, Spain.ORCID 0000-0003-1812-9323
María D Pinazo-DuranOphthalmic Research Unit "Santiago Grisolía" Foundation for the Promotion of Health and Biomedical Research of Valencia FISABIO, 46017 Valencia, Spain.
Universitat de València · ESInstituto de Salud Carlos III · ESUniversidad Complutense de Madrid · ESFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana · ES

Funding

Instituto de Salud Carlos III RD16/0008/0022
6 · The paper itself

Abstract

Adherence to a healthy diet offers a valuable intervention to compete against the increasing cases of ocular diseases worldwide, such as dry eye disorders, myopia progression, cataracts, glaucoma, diabetic retinopathy, or age macular degeneration. Certain amounts of micronutrients must be daily provided for proper functioning of the visual system, such as vitamins, carotenoids, trace metals and omega-3 fatty acids. Among natural foods, the following have to be considered for boosting eye/vision health: fish, meat, eggs, nuts, legumes, citrus fruits, nuts, leafy green vegetables, orange-colored fruits/vegetables, olives-olive oil, and dairy products. Nutritional supplements have received much attention as potential tools for managing chronic-degenerative ocular diseases. A systematic search of PubMed, Web of Science, hand-searched publications and historical archives were performed by the professionals involved in this study, to include peer-reviewed articles in which natural food, nutrient content, and its potential relationship with ocular health. Five ophthalmologists and two researchers collected the characteristics, quality and suitability of the above studies. Finally, 177 publications from 1983 to 2021 were enclosed, mainly related to natural food, Mediterranean diet (MedDiet) and nutraceutic supplementation. For the first time, original studies with broccoli and tigernut (

Indexed as

antioxidant/anti-inflammatory/neuroprotective propertiesbroccolieye diseasesMediterranean dietnatural foodnutritional supplementssaffrontigernuts-chufa de Valenciawalnuts

Identifiers

PMID34071459
PMCPMC8229954
OpenAlexW3164587949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.