Evidence map›Paper›PMID 34071377›Full record

ArticleBrain sciences2021

fMRI Investigation of Semantic Lexical Processing in Healthy Control and Alzheimer's Disease Subjects Using Naming Task: A Preliminary Study.

Yen-Ting Chen, Chun-Ju Hou, Natan Derek, Min-Wei Huang

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In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yen-Ting ChenDepartment of Electrical Engineering, Southern Taiwan University of Science and Technology, Tainan 701, Taiwan.
Chun-Ju HouDepartment of Electrical Engineering, Southern Taiwan University of Science and Technology, Tainan 701, Taiwan.ORCID 0000-0002-0268-4392
Natan DerekDepartment of Electrical Engineering, Southern Taiwan University of Science and Technology, Tainan 701, Taiwan.
Min-Wei HuangMOST AI Biomedical Research Center at NCKU, Tainan 701, Taiwan.

Funding

Ministry of Science and Technology Taiwan MOST 108-2634-F-367-001Ministry of Science and Technology Taiwan MOST 109-2634-F-367-001Ministry of Science and Technology Taiwan MOST 110-2634-F-367-001The Allied Advanced Intelligent Biomedical Research Center (A2 IBRC) under the Higher Education Sprout Project of Ministry of Education 13001090182- EDU
6 · The paper itself

Abstract

For decades, scientists have been trying to solve the problem of dementia, with no cure currently available. Semantic-lexical impairment is well established as the early critical sign of dementia, although there are still gaps in knowledge that must be investigated. In this study, we used fMRI to observe the neural activity of 31 subjects, including 16 HC (Healthy Control) and 15 AD (Alzheimer's Disease), who participated in the naming task. The neuropsychology profile of HC (Healthy Control) and AD (Alzheimer's Disease) are discussed in this study. The involvement of FG (Fusiform Gyrus) and IFG (Inferior Frontal Gyrus) shows dominant activation in both of the groups. We observed a decrease in neural activity in the AD group, resulting in semantic deficit problems in this preliminary study. Furthermore, ROI analysis was performed and revealed both hyperactivation and hypoactivation in the AD group. The compensatory mechanism demonstrated during the task, due to the effort required to identify an animal's name, represents the character profile of AD.

Indexed as

Alzheimer’s diseasefMRI analysisnaming tasksemantic–lexical processing

Identifiers

PMID34071377
PMCPMC8226532

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.