Evidence map›Paper›PMID 34071369›Full record

ReviewMolecules (Basel, Switzerland)2021

Antitumor Activity and Potential Mechanism of Novel Fullerene Derivative Nanoparticles.

Lianjie Ye, Larwubah Kollie, Xing Liu, Wei Guo, Xiangxian Ying, Jun Zhu, Shengjie Yang, Meilan Yu

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Review
  2. Review
  3. Implications of the molecular toxicity and cytocompatibility by the nano-caged CNaunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Fullerene CInternational journal of molecular sciences · 2024
    Article
  15. Article
  16. Review
  17. Article
  18. Influence of CCancers · 2023
    Article
  19. Review
  20. Carbon Nanomaterials: Emerging Roles in Immuno-Oncology.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lianjie YeCollege of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.ORCID 0000-0001-6265-9124
Larwubah KollieCollege of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Xing LiuCollege of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Wei GuoCollege of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Xiangxian YingCollege of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310014, China.ORCID 0000-0002-2885-2657
Jun ZhuHangzhou Wahaha Co., Ltd., Hangzhou 310018, China.
Shengjie YangShaoxing Academy of Biomedicine, Zhejiang Sci-Tech University, Shaoxing 312030, China.
Meilan YuCollege of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.

Funding

the Science Foundation of Zhejiang Sci-Tech University (ZSTU) No.15042089-Y.
6 · The paper itself

Abstract

The development of novel nanoparticles as a new generation therapeutic drug platform is an active field of chemistry and cancer research. In recent years, fullerene nanoparticles have received extensive attention due to their unique physical and chemical properties. Properly modified fullerene nanoparticles have excellent biocompatibility and significant anti-tumor activity, which makes them have broad application prospects in the field of cancer therapy. Therefore, understanding the anti-tumor mechanism of fullerene nanoparticles is of great significance for the design and development of anti-tumor drugs with low toxicity and high targeting. This review has focused on various anti-tumor mechanisms of fullerene derivatives and discusses their toxicity and their distribution in organisms. Finally, the review points out some urgent problems that need solution before fullerene derivatives as a new generation of anti-tumor nano-drug platform enter clinical research.

Indexed as

AnimalsAntineoplastic AgentsCell CycleCell Line, TumorCell ProliferationChemistry, PharmaceuticalDrug Delivery SystemsDrug DesignDrug Screening Assays, AntitumorFullerenesHumansMiceNanomedicineNanoparticlesNeoplasm MetastasisNeoplasmsAntineoplastic AgentsFullerenesanti-tumorcancerfullerenenanomedicinenanoparticle

Identifiers

PMID34071369
PMCPMC8198614

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.