Evidence map›Paper›PMID 34071322›Full record

ArticleInternational journal of molecular sciences2021

Histone Deacetylase Inhibitors Ameliorate Morphological Defects and Hypoexcitability of iPSC-Neurons from Rubinstein-Taybi Patients.

Valentina Alari, Paolo Scalmani, Paola Francesca Ajmone, Sara Perego, Sabrina Avignone, Ilaria Catusi, Paola Adele Lonati, Maria Orietta Borghi, Palma Finelli, Benedetta Terragni and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Deficiency ofProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Valentina AlariResearch Laboratory of Medical Cytogenetics and Molecular Genetics, IRCCS Istituto Auxologico Italiano, Via Ariosto 13, 20145 Milan, Italy.
Paolo ScalmaniDepartment of Neurophysiology and Diagnostic Epileptology, IRCCS Foundation C. Besta Neurological Institute, 20133 Milan, Italy.ORCID 0000-0002-3992-0926
Paola Francesca AjmoneChild and Adolescent Neuropsychiatric Service (UONPIA), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy.
Sara PeregoResearch Laboratory of Medical Cytogenetics and Molecular Genetics, IRCCS Istituto Auxologico Italiano, Via Ariosto 13, 20145 Milan, Italy.
Sabrina AvignoneDepartment of Neuroradiology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.ORCID 0000-0001-8714-0775
Ilaria CatusiResearch Laboratory of Medical Cytogenetics and Molecular Genetics, IRCCS Istituto Auxologico Italiano, Via Ariosto 13, 20145 Milan, Italy.ORCID 0000-0002-8108-1521
Paola Adele LonatiDepartment of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.
Maria Orietta BorghiDepartment of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.ORCID 0000-0001-8967-9678
Palma FinelliResearch Laboratory of Medical Cytogenetics and Molecular Genetics, IRCCS Istituto Auxologico Italiano, Via Ariosto 13, 20145 Milan, Italy.ORCID 0000-0001-8464-6906
Benedetta TerragniDepartment of Neurophysiology and Diagnostic Epileptology, IRCCS Foundation C. Besta Neurological Institute, 20133 Milan, Italy.
Massimo MantegazzaDepartment of Neurophysiology and Diagnostic Epileptology, IRCCS Foundation C. Besta Neurological Institute, 20133 Milan, Italy.ORCID 0000-0002-1070-7929
Silvia RussoResearch Laboratory of Medical Cytogenetics and Molecular Genetics, IRCCS Istituto Auxologico Italiano, Via Ariosto 13, 20145 Milan, Italy.ORCID 0000-0002-5893-0193
Lidia LarizzaResearch Laboratory of Medical Cytogenetics and Molecular Genetics, IRCCS Istituto Auxologico Italiano, Via Ariosto 13, 20145 Milan, Italy.ORCID 0000-0002-1367-7227
IRCCS Istituto Auxologico Italiano · ITUniversity of Milan · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITCentre National de la Recherche Scientifique · FR

Funding

ERA-NET-NEURON JTC2015 ChromiSynMinistry of Health RC 08C921
6 · The paper itself

Abstract

Rubinstein-Taybi syndrome (RSTS) is a rare neurodevelopmental disorder caused by mutations in

Indexed as

AdolescentCell DifferentiationCells, CulturedCell SurvivalChildE1A-Associated p300 ProteinElectroencephalographyHistone Deacetylase InhibitorsHumansHydroxamic AcidsInduced Pluripotent Stem CellsMagnetic Resonance ImagingMaleMembrane PotentialsMutationNeuronsE1A-Associated p300 ProteinEP300 protein, humanHistone Deacetylase InhibitorsHydroxamic Acidstrichostatin Ahistone deacetylase inhibitorshypoexcitabilityintellectual disabilityiPSC-neuronsmorphological abnormalitiespartial rescueRubinstein-Taybitrichostatin Avalproic acid

Identifiers

PMID34071322
PMCPMC8197986
OpenAlexW3165862613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.