Evidence map›Paper›PMID 34071318›Full record

ArticleInternational journal of molecular sciences2021

The Amino Acid Transporter Mct10/Tat1 Is Important to Maintain the TSH Receptor at Its Canonical Basolateral Localization and Assures Regular Turnover of Thyroid Follicle Cells in Male Mice.

Vaishnavi Venugopalan, Alaa Al-Hashimi, Jonas Weber, Maren Rehders, Maria Qatato, Eva K Wirth, Ulrich Schweizer, Heike Heuer, François Verrey, Klaudia Brix

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Vaishnavi VenugopalanDepartment of Life Sciences and Chemistry, Focus Area HEALTH, Jacobs University Bremen, Campus Ring 1, D-28759 Bremen, Germany.ORCID 0000-0001-6772-6787
Alaa Al-HashimiDepartment of Life Sciences and Chemistry, Focus Area HEALTH, Jacobs University Bremen, Campus Ring 1, D-28759 Bremen, Germany.
Jonas WeberDepartment of Life Sciences and Chemistry, Focus Area HEALTH, Jacobs University Bremen, Campus Ring 1, D-28759 Bremen, Germany.
Maren RehdersDepartment of Life Sciences and Chemistry, Focus Area HEALTH, Jacobs University Bremen, Campus Ring 1, D-28759 Bremen, Germany.
Maria QatatoDepartment of Life Sciences and Chemistry, Focus Area HEALTH, Jacobs University Bremen, Campus Ring 1, D-28759 Bremen, Germany.
Eva K WirthBerlin Institute of Health, Department of Endocrinology and Metabolism, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Hessische Str. 3-4, D-10115 Berlin, Germany.
Ulrich SchweizerInstitut für Biochemie und Molekularbiologie, Universitätsklinikum Bonn, Nußallee 11, D-53115 Bonn, Germany.
Heike HeuerDepartment of Endocrinology, Diabetes and Metabolism, University of Duisburg-Essen, Universitätsklinikum Essen, Hufelandstr. 55, D-45147 Essen, Germany.
François VerreyPhysiologisches Institut, Universität Zürich, Winterthurerstr. 190, CH-8057 Zürich, Switzerland.
Klaudia BrixDepartment of Life Sciences and Chemistry, Focus Area HEALTH, Jacobs University Bremen, Campus Ring 1, D-28759 Bremen, Germany.ORCID 0000-0002-4476-0357
Constructor University · DEEssen University Hospital · DEHumboldt-Universität zu Berlin · DEUniversity Hospital Bonn · DEUniversity of Zurich · CH

Funding

Charité - Universitätsmedizin Berlin Rahel-Hirsch stipend to E.K.W.Deutsche Forschungsgemeinschaft BR 1308/11-1, 11-2Deutsche Forschungsgemeinschaft HE 3418/7-1, 7-2Deutsche Forschungsgemeinschaft SCHW 914/6-1Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 31_166430/1 to F.V.
6 · The paper itself

Abstract

Cathepsin K-mediated thyroglobulin proteolysis contributes to thyroid hormone (TH) liberation, while TH transporters like Mct8 and Mct10 ensure TH release from thyroid follicles into the blood circulation. Thus, thyroid stimulating hormone (TSH) released upon TH demand binds to TSH receptors of thyrocytes, where it triggers Gα

Indexed as

Amino Acid Transport Systems, NeutralAnimalsCathepsin KFluorescent Antibody Technique, IndirectMaleMiceMice, Inbred C57BLMice, KnockoutMicroscopy, ConfocalReceptors, ThyrotropinThyroglobulinThyroid Epithelial CellsThyroid GlandThyroid HormonesThyrotropinAmino Acid Transport Systems, NeutralCathepsin KReceptors, ThyrotropinSlc16a10 protein, mouseThyroglobulinThyroid HormonesThyrotropinmonocarboxylate transporter 10/Scl16a10thyrocyte survivalthyroid gland architectureTSH receptor signaling

Identifiers

PMID34071318
PMCPMC8198332
OpenAlexW3165493387

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.