Evidence map›Paper›PMID 34071308›Full record

ArticleBiomedicines2021

Clinical Assessment of Endothelial Function in Convalescent COVID-19 Patients Undergoing Multidisciplinary Pulmonary Rehabilitation.

Pasquale Ambrosino, Antonio Molino, Ilenia Calcaterra, Roberto Formisano, Silvia Stufano, Giorgio Alfredo Spedicato, Andrea Motta, Antimo Papa, Matteo Nicola Dario Di Minno, Mauro Maniscalco

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

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  10. Vascular mechanisms of post-COVID-19 conditions: Rho-kinase is a novel target for therapy.European heart journal. Cardiovascular pharmacotherapy · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Pasquale AmbrosinoIstituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.ORCID 0000-0002-9398-0428
Antonio MolinoDepartment of Respiratory Medicine, Federico II University, 80131 Naples, Italy.ORCID 0000-0001-6966-9640
Ilenia CalcaterraDepartment of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy.ORCID 0000-0001-8077-2809
Roberto FormisanoIstituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.
Silvia StufanoIstituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.
Giorgio Alfredo SpedicatoDepartment of Data Analytics and Actuarial Science, Unipol Group, 40128 Bologna, Italy.ORCID 0000-0002-0315-8888
Andrea MottaInstitute of Biomolecular Chemistry, National Research Council, ICB-CNR, 80078 Pozzuoli, Naples, Italy.ORCID 0000-0002-8643-658X
Antimo PapaIstituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.
Matteo Nicola Dario Di MinnoDepartment of Translational Medical Sciences, Federico II University, 80131 Naples, Italy.ORCID 0000-0001-8059-3819
Mauro ManiscalcoIstituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.ORCID 0000-0001-6751-9921
Istituti Clinici Scientifici Maugeri · ITFederico II University Hospital · ITIstituto di Chimica Biomolecolare · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGrowing evidence points to a key role of endothelial dysfunction in the pathogenesis of COVID-19. In this study, we evaluated changes in endothelium-dependent flow-mediated dilation (FMD) in a cohort of convalescent COVID-19 patients undergoing pulmonary rehabilitation (PR).

methodsAfter swab test negativization, convalescent COVID-19 patients referring to a post-acute care facility for PR were consecutively screened for inclusion. Study procedures were performed at the time of hospitalization and discharge.

resultsWe enrolled 82 convalescent COVID-19 patients (85.4% males, mean age 60.4 years). After PR, a significant improvement in most pulmonary function tests and exercise capacity was documented. FMD changed from 2.48% ± 2.01 to 4.24% ± 2.81 (

conclusionsClinically evaluated endothelial function improves after PR in convalescent COVID-19 patients. A direct and persistent association between the severity of pulmonary and vascular disease can be hypothesized. Endothelial function testing may be useful in the follow-up of convalescent COVID-19 patients.

Indexed as

biomarkersCOVID-19disabilityendothelial functionexerciseoutcomesrehabilitation

Identifiers

PMID34071308
PMCPMC8226503
OpenAlexW3165320859

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.