Evidence map›Paper›PMID 34071293›Full record

ArticleJournal of clinical medicine2021

Vitamin D Levels in COVID-19 Outpatients from Western Mexico: Clinical Correlation and Effect of Its Supplementation.

Gabriela Athziri Sánchez-Zuno, Guillermo González-Estevez, Mónica Guadalupe Matuz-Flores, Gabriela Macedo-Ojeda, Jorge Hernández-Bello, Jesús Carlos Mora-Mora, Edsaúl Emilio Pérez-Guerrero, Mariel García-Chagollán, Natali Vega-Magaña, Francisco Javier Turrubiates-Hernández and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 8 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 8 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Article
  11. Investigating the role of the mPGES-PGE₂-EP4 pathway inFrontiers in veterinary science · 2025
    Article
  12. Review
  13. Article
  14. Vitamin D supplementations and mortality among patients with moderate/severe COVID-19: A meta-analysis of randomized controlled trials.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024
    Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Gabriela Athziri Sánchez-ZunoInstitute of Research in Biomedical Sciences, Department of Medical Clinics, University Center of Health Sciences (CUCS), Edificio Q, 950 Sierra Mojada, Guadalajara 44340, Mexico.ORCID 0000-0002-4390-8604
Guillermo González-EstevezInstitute of Research in Biomedical Sciences, Department of Medical Clinics, University Center of Health Sciences (CUCS), Edificio Q, 950 Sierra Mojada, Guadalajara 44340, Mexico.
Mónica Guadalupe Matuz-FloresInstitute of Research in Biomedical Sciences, Department of Medical Clinics, University Center of Health Sciences (CUCS), Edificio Q, 950 Sierra Mojada, Guadalajara 44340, Mexico.
Gabriela Macedo-OjedaInstitute of Research in Biomedical Sciences, Department of Medical Clinics, University Center of Health Sciences (CUCS), Edificio Q, 950 Sierra Mojada, Guadalajara 44340, Mexico.ORCID 0000-0002-3815-2160
Jorge Hernández-BelloInstitute of Research in Biomedical Sciences, Department of Medical Clinics, University Center of Health Sciences (CUCS), Edificio Q, 950 Sierra Mojada, Guadalajara 44340, Mexico.
Jesús Carlos Mora-MoraLaboratory for the Diagnosis of Emerging and Reemerging Diseases (LaDEER), University Center for Health Sciences (CUCS), Edificio Q, 950 Sierra Mojada, Guadalajara 44340, Mexico.
Edsaúl Emilio Pérez-GuerreroInstitute of Research in Biomedical Sciences, Department of Medical Clinics, University Center of Health Sciences (CUCS), Edificio Q, 950 Sierra Mojada, Guadalajara 44340, Mexico.ORCID 0000-0002-0007-1824
Mariel García-ChagollánInstitute of Research in Biomedical Sciences, Department of Medical Clinics, University Center of Health Sciences (CUCS), Edificio Q, 950 Sierra Mojada, Guadalajara 44340, Mexico.
Natali Vega-MagañaInstitute of Research in Biomedical Sciences, Department of Medical Clinics, University Center of Health Sciences (CUCS), Edificio Q, 950 Sierra Mojada, Guadalajara 44340, Mexico.ORCID 0000-0003-4749-2498
Francisco Javier Turrubiates-HernándezInstitute of Research in Biomedical Sciences, Department of Medical Clinics, University Center of Health Sciences (CUCS), Edificio Q, 950 Sierra Mojada, Guadalajara 44340, Mexico.ORCID 0000-0001-9637-168X
Andrea Carolina Machado-SulbaranInstitute for Research in Childhood and Adolescent Cancer (INICIA), Department of Human Reproduction, Child Growth and Development Clinics, University Center for Health Sciences (CUCS), Edificio Q, 950 Sierra Mojada, Guadalajara 44340, Mexico.
José Francisco Muñoz-ValleInstitute of Research in Biomedical Sciences, Department of Medical Clinics, University Center of Health Sciences (CUCS), Edificio Q, 950 Sierra Mojada, Guadalajara 44340, Mexico.ORCID 0000-0002-2272-9260
Universidad de Guadalajara · MX

Funding

Consejo Nacional de Ciencia y Tecnología A1-S-8774
6 · The paper itself

Abstract

backgroundThe immunomodulatory effects of vitamin D are known to be beneficial in viral infections; it is also known that its deficiency is associated with a prognosis more critical of Coronavirus Disease 2019. This study aimed to determine baseline vitamin D serum concentrations and the effects of its supplementation in asymptomatic or mildly symptomatic Coronavirus Disease 2019 outpatients.

methods42 outpatients were included, 22 of which received a supplement of 10,000 IU of vitamin D3 for 14 days; the remaining 20 outpatients were designated as a control group. Serum levels of transferrin, ferritin, vitamin D, and D-dimer were measured at baseline in both groups. After 14 days, serum levels of total vitamin D were determined in the supplemented group.

resultsAt baseline, only 19% of infected outpatients had vitamin D levels corresponding to sufficiency. All outpatients with vitamin D insufficiency had at least one symptom associated with the disease, while only 75% of patients with symptoms presented sufficiency. On the seventh and fourteenth day of follow-up, the supplemented group presented fewer symptoms with respect to those non-supplemented. A vitamin D3 dose of 10,000 IU/daily for 14 days was sufficient to raise vitamin D serum concentrations.

conclusionsImmunomodulatory effects of vitamin D appear to be linked to the development of symptoms in positive outpatients. Vitamin D supplementation could have significant benefits in the Western Mexican population.

Indexed as

biochemical parameterscholecalciferolcoronavirusCOVID-19ergocalciferolLatin AmericaSARS-CoV-2supplementationvitamin D

Identifiers

PMID34071293
PMCPMC8198869
OpenAlexW3165721616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.