ArticleDiagnostics (Basel, Switzerland)2021
Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI.
Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Imaging findings of irritable bowel syndrome patients, and the diagnostic value of irritable bowel syndrome: A systematic review.World journal of methodology · 2025Article
- Colon length in pediatric health and constipation measured using magnetic resonance imaging and three dimensional skeletonization.PloS one · 2024Article
- Myocardial work in children with Wolff-Parkinson-White syndrome.The international journal of cardiovascular imaging · 2023Article
- Correlation between Constipation Symptoms and Abdominal CT Imaging: A Cross-Sectional Pilot Study.Journal of clinical medicine · 2023Article
- Aged black tea alleviates constipation in mice by modulating intestinal neurotransmitters and decreasing AQP3 and AQP9 expression.Food & nutrition research · 2023Article
- Colonic volume in patients with functional constipation or irritable bowel syndrome determined by magnetic resonance imaging.Neurogastroenterology and motility · 2022Article
- Alterations in infant gut microbiome composition and metabolism after exposure to glyphosate and Roundup and/or a spore-based formulation using the SHIME technology.Gut microbiome (Cambridge, England) · 2022Article
- Quantification of Fluid Volume and Distribution in the Paediatric Colon via Magnetic Resonance Imaging.Pharmaceutics · 2021Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundFunctional constipation in children is common. Management of this condition can be challenging and is often based on symptom reports. Increased, objective knowledge of colonic volume changes in constipation compared to health could provide additional information. However, very little data on paediatric colonic volume is available except from methods that are invasive or require unphysiological colonic preparations.
objectives(1) To measure volumes of the undisturbed colon in children with functional constipation (FC) using magnetic resonance imaging (MRI) and provide initial normal range values for healthy controls, and (2) to investigate possible correlation of colonic volume with whole gut transit time (WGTT).
methodsTotal and regional (ascending, transverse, descending, sigmoid, and rectum) colon volumes were measured from MRI images of 35 participants aged 7-18 years (16 with FC and 19 healthy controls), and corrected for body surface area. Linear regression was used to explore the relationship between total colon volume and WGTT.
resultsTotal colonic volume was significantly higher, with a median (interquartile range) of 309 mL (243-384 mL) for the FC group than for the healthy controls of 227 mL (180-263 mL). The largest increase between patients and controls was in the sigmoid colon-rectum region. In a linear regression model, there was a positive significant correlation between total colonic volume and WGTT (
conclusionsThis initial study shows increased volumes of the colon in children with FC, in a physiological state, without use of any bowel preparation. Increased knowledge of colonic morphology may improve understanding of FC in this age group and help to direct treatment.
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