Evidence map›Paper›PMID 34071180›Full record

ArticleMarine drugs2021

Fish Sidestream-Derived Protein Hydrolysates Suppress DSS-Induced Colitis by Modulating Intestinal Inflammation in Mice.

Maria G Daskalaki, Konstantinos Axarlis, Tone Aspevik, Michail Orfanakis, Ourania Kolliniati, Ioanna Lapi, Maria Tzardi, Eirini Dermitzaki, Maria Venihaki, Katerina Kousoulaki and 1 more

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Article
  3. Diet supplementation with the macroalgaeFrontiers in nutrition · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Cytoprotective Effects of Fish Protein Hydrolysates against HAntioxidants (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Maria G DaskalakiLaboratory of Clinical Chemistry, Medical School, University of Crete, 70013 Heraklion, Greece.ORCID 0000-0002-4424-2779
Konstantinos AxarlisLaboratory of Clinical Chemistry, Medical School, University of Crete, 70013 Heraklion, Greece.
Tone AspevikDepartment of Nutrition and Feed Technology, Nofima AS, 5141 Bergen, Norway.
Michail OrfanakisLaboratory of Clinical Chemistry, Medical School, University of Crete, 70013 Heraklion, Greece.
Ourania KolliniatiLaboratory of Clinical Chemistry, Medical School, University of Crete, 70013 Heraklion, Greece.
Ioanna LapiLaboratory of Clinical Chemistry, Medical School, University of Crete, 70013 Heraklion, Greece.
Maria TzardiLaboratory of Pathology, School of Medicine, University of Crete, 70013 Heraklion, Greece.
Eirini DermitzakiLaboratory of Clinical Chemistry, Medical School, University of Crete, 70013 Heraklion, Greece.
Maria VenihakiLaboratory of Clinical Chemistry, Medical School, University of Crete, 70013 Heraklion, Greece.ORCID 0000-0002-3789-8032
Katerina KousoulakiDepartment of Nutrition and Feed Technology, Nofima AS, 5141 Bergen, Norway.ORCID 0000-0002-8021-5452
Christos TsatsanisLaboratory of Clinical Chemistry, Medical School, University of Crete, 70013 Heraklion, Greece.ORCID 0000-0003-1214-4151
University of Crete · GRNofima · NO

Funding

General secreteriat for Research and Technology Hellas MIS 5002670Horizon 2020 Framework Programme 790956
6 · The paper itself

Abstract

Inflammatory bowel disease is characterized by extensive intestinal inflammation, and therapies against the disease target suppression of the inflammatory cascade. Nutrition has been closely linked to the development and suppression of inflammatory bowel disease, which to a large extent is attributed to the complex immunomodulatory properties of nutrients. Diets containing fish have been suggested to promote health and suppress inflammatory diseases. Even though most of the health-promoting properties of fish-derived nutrients are attributed to fish oil, the potential health-promoting properties of fish protein have not been investigated. Fish sidestreams contain large amounts of proteins, currently unexploited, with potential anti-inflammatory properties, and may possess additional benefits through bioactive peptides and free amino acids. In this project, we utilized fish protein hydrolysates, based on mackerel and salmon heads and backbones, as well as flounder skin collagen. Mice fed with a diet supplemented with different fish sidestream-derived protein hydrolysates (5%

Indexed as

FishesWaste ProductsAnimalsAnti-Inflammatory AgentsColitisColonCytokinesDextran SulfateDietary SupplementsFemaleFood IndustryMiceMice, Inbred C57BLProtein HydrolysatesAnti-Inflammatory AgentsCytokinesDextran SulfateProtein HydrolysatesWaste Productschemokinescolitiscytokinesfish protein hydrolysatesIL-10IL-6inflammation

Identifiers

PMID34071180
PMCPMC8228426
OpenAlexW3165216212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.