Evidence map›Paper›PMID 34071169›Full record

ArticleInternational journal of molecular sciences2021

Investigating the Antifungal Mechanism of Action of Polygodial by Phenotypic Screening in

Purity N Kipanga, Liesbeth Demuyser, Johannes Vrijdag, Elja Eskes, Petra D'hooge, Josphat Matasyoh, Geert Callewaert, Joris Winderickx, Patrick Van Dijck, Walter Luyten

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Molecules (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Purity N KipangaFaculty of Pharmaceutical Sciences, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0003-4605-1404
Liesbeth DemuyserLaboratory of Molecular Cell Biology, Department of Biology, KU Leuven, 3000 Leuven, Belgium.
Johannes VrijdagDepartment of Chemistry, Molecular Design and Synthesis, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-8085-3390
Elja EskesLaboratory of Molecular Cell Biology, Department of Biology, KU Leuven, 3000 Leuven, Belgium.
Petra D'hoogeThe Yeast Hub Lab, KU Leuven, Campus Kulak, 8500 Kortrijk, Belgium.
Josphat MatasyohDepartment of Chemistry, Egerton University, Njoro 20107, Kenya.
Geert CallewaertThe Yeast Hub Lab, KU Leuven, Campus Kulak, 8500 Kortrijk, Belgium.
Joris WinderickxDepartment of Biology, Functional Biology, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0003-3133-7733
Patrick Van DijckLaboratory of Molecular Cell Biology, Department of Biology, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-1542-897X
Walter LuytenDepartment of Biology, Animal Physiology and Neurobiology, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-3302-5816
KU Leuven · BEVIB-KU Leuven Center for Microbiology · BEEgerton University · KE

Funding

KU Leuven C14/17/063
6 · The paper itself

Abstract

Polygodial is a "hot" peppery-tasting sesquiterpenoid that was first described for its anti-feedant activity against African armyworms. Using the haploid deletion mutant library of

Indexed as

Antifungal AgentsCalciumDrug Resistance, FungalHomeostasisHydrogen-Ion ConcentrationMechanistic Target of Rapamycin Complex 1Microbial Sensitivity TestsMitochondriaMitochondrial ProteinsNucleosomesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSesquiterpenesSignal TransductionVacuolar Proton-Translocating ATPasesAntifungal AgentsCalciumMechanistic Target of Rapamycin Complex 1Mitochondrial ProteinsNucleosomespolygodialSaccharomyces cerevisiae ProteinsSesquiterpenesVacuolar Proton-Translocating ATPasesantifungalCa2+ signaling and Ca2+ homeostasishaploid deletion mutant libraryPolygodialSaccharomyces cerevisiaeTORC1 signalingubiquitinvacuolar pHV-ATPase

Identifiers

PMID34071169
PMCPMC8198865
OpenAlexW3164980862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.