Evidence map›Paper›PMID 34071152›Full record

ArticleInternational journal of molecular sciences2021

A Single-Domain Antibody-Based Anti-PSMA Recombinant Immunotoxin Exhibits Specificity and Efficacy for Prostate Cancer Therapy.

Yutong Xing, Keyuan Xu, Shixiong Li, Li Cao, Yue Nan, Qiyu Li, Wenjing Li, Zhangyong Hong

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Nanobodies: a new potential for prostate cancer treatment.Journal of cancer research and clinical oncology · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Enhanced cytotoxicity of aFrontiers in pharmacology · 2023
    Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yutong XingState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
Keyuan XuState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
Shixiong LiState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
Li CaoState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.ORCID 0000-0001-5194-5002
Yue NanState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
Qiyu LiState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
Wenjing LiState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
Zhangyong HongState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.ORCID 0000-0002-0086-4541
Nankai University · CN

Funding

National Natural Science Foundation of China 31970873
6 · The paper itself

Abstract

Prostate cancer (PCa) is the second most common cancer in men, causing more than 300,000 deaths every year worldwide. Due to their superior cell-killing ability and the relative simplicity of their preparation, immunotoxin molecules have great potential in the clinical treatment of cancer, and several such molecules have been approved for clinical application. In this study, we adopted a relatively simple strategy based on a single-domain antibody (sdAb) and an improved

Indexed as

Molecular Targeted TherapyAdenocarcinomaAnimalsAntibody SpecificityAntigen-Antibody ReactionsAntigens, NeoplasmAntigens, SurfaceAntineoplastic Agents, ImmunologicalCell Line, TumorDrug Screening Assays, AntitumorGlutamate Carboxypeptidase IIHumansImmunotoxinsMaleMaximum Tolerated DoseMiceAntigens, NeoplasmAntigens, SurfaceAntineoplastic Agents, ImmunologicalFOLH1 protein, humanGlutamate Carboxypeptidase IIImmunotoxinsRecombinant Fusion ProteinsSingle-Domain AntibodiesimmunotoxinsPEprostate carcinomaPSMA (prostate-specific membrane antigen)sdAbs (single-domain antibodies)

Identifiers

PMID34071152
PMCPMC8197099
OpenAlexW3164452959

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.