Evidence map›Paper›PMID 34071132›Full record

ArticleInternational journal of molecular sciences2021

Demethoxycurcumin Suppresses Human Brain Glioblastoma Multiforme GBM 8401 Cell Xenograft Tumor in Nude Mice

Yi-Ping Huang, Yi-Shih Ma, Chao-Lin Kuo, Ching-Lung Liao, Po-Yuan Chen, Shu-Fen Peng, Fei-Ting Hsu, Kuang-Chi Lai

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yi-Ping HuangDepartment of Physiology, School of Medicine, China Medical University, Taichung 406, Taiwan.
Yi-Shih MaSchool of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung 840, Taiwan.
Chao-Lin KuoDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 406, Taiwan.
Ching-Lung LiaoCollege of Chinese Medicine, School of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung 406, Taiwan.
Po-Yuan ChenDepartment of Biological Science and Technology, China Medical University, Taichung 406, Taiwan.ORCID 0000-0003-2129-2586
Shu-Fen PengDepartment of Biological Science and Technology, China Medical University, Taichung 406, Taiwan.
Fei-Ting HsuDepartment of Biological Science and Technology, China Medical University, Taichung 406, Taiwan.
Kuang-Chi LaiDepartment of Medical Laboratory Science and Biotechnology, College of Medical Technology, Chung Hwa University of Medical Technology, Tainan 717, Taiwan.
China Medical University · TWChung Hwa University of Medical Technology · TWE-Da Hospital · TW

Funding

China Medical University, Taiwan CMU107-TU-05Experiments and data analysis were performed in part through the use of the Medical Research Core Facilities Center, Office of Research & Development at China Medical University, Taichung, Taiwan, ROC. N/A
6 · The paper itself

Abstract

Demethoxycurcumin (DMC), a derivate of curcumin, has been shown to induce apoptotic cell death in human glioblastoma multiforme GBM 8401 cells via cell cycle arrest and induction of cell apoptosis. However, there is no report showing DMC suppresses glioblastoma multiforme cells

Indexed as

AnimalsAntineoplastic Agents, PhytogenicApoptosisbcl-2-Associated X ProteinBrain NeoplasmsCell Line, TumorDiarylheptanoidsGenes, ReporterGlioblastomaHumansLiverMaleMiceMice, NudeNeoplasm ProteinsProto-Oncogene Proteins c-bcl-2Antineoplastic Agents, PhytogenicBAX protein, humanbcl-2-Associated X ProteindemethoxycurcuminDiarylheptanoidsNeoplasm ProteinsProto-Oncogene Proteins c-bcl-2XIAP protein, humanX-Linked Inhibitor of Apoptosis Proteindemethoxycurcumin (DMC)glioblastoma multiformein vivonude micexenograft tumor

Identifiers

PMID34071132
PMCPMC8197162
OpenAlexW3164623706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.