Evidence map›Paper›PMID 34071058›Full record

SynthesisInternational journal of environmental research and public health2021

Maternal and Neonatal Oral Microbiome Developmental Patterns and Correlated Factors: A Systematic Review-Does the Apple Fall Close to the Tree?

Gianna Maria Nardi, Roberta Grassi, Artnora Ndokaj, Michela Antonioni, Maciej Jedlinski, Gabriele Rumi, Katarzyna Grocholewicz, Irena Dus-Ilnicka, Felice Roberto Grassi, Livia Ottolenghi and 1 more

Abstract readSystematic Review
In one paragraph

Synthesis in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
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  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Acquisition of the Oral Microbiome.Advances in experimental medicine and biology · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Metabarcoding analysis of oral microbiome during pregnancy.Frontiers in cellular and infection microbiology · 2024
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gianna Maria NardiDepartment of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.ORCID 0000-0002-9329-9149
Roberta GrassiDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
Artnora NdokajDepartment of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.ORCID 0000-0002-1400-8607
Michela AntonioniDepartment of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.
Maciej JedlinskiDepartment of Interdisciplinary Dentistry, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.ORCID 0000-0003-3446-6119
Gabriele RumiFoundation Policlinico Universitario Agostino Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy.
Katarzyna GrocholewiczDepartment of Interdisciplinary Dentistry, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.ORCID 0000-0002-1468-4664
Irena Dus-IlnickaDepartment of Oral Pathology, Wroclaw Medical University, ul. Krakowska 26, 52-425 Wrocław, Poland.ORCID 0000-0002-4745-2560
Felice Roberto GrassiDepartment of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, 70122 Bari, Italy.
Livia OttolenghiDepartment of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.ORCID 0000-0001-7390-4316
Marta MazurDepartment of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.ORCID 0000-0002-0525-681X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: The purpose of the study was to comprehensively analyze the relationship between the mother's oral microbiome, modes of delivery and feeding, and the formation of the newborn child's oral microbiome. (2) Methods: This systematic review included a search through MEDLINE (PubMed) database (from 2010 to July 2020). Research was registered in PROSPERO under the number CRD42021241044. (3) Results: Of the 571 studies, 11 met the inclusion criteria. Included studies were classified according to (i) child's delivery mode, (ii) maternal exposure to antibiotics and disinfectants, and (iii) feeding type. (4) Conclusions: The interpretation of these papers shows that the type of delivery, maternal exposure to disinfectants and antibiotics during delivery, maternal health classed as overweight, gestational diabetes mellitus, and feeding type are correlated to changes in the maternal and neonatal early oral microbiomes, based on the analysis provided in this systematic review. Because no evidence exists regarding the impact of maternal diet and maternal oral health on the establishment and development of the early oral newborn microbiome, more studies are needed to deepen the knowledge and understanding of the subject and develop preventive and therapeutic strategies of support to pregnant women.

Indexed as

Diabetes, GestationalMicrobiotaFemaleHumansInfant, NewbornOverweightPregnancyantibioticsbreastfeedingc-sectionearly lifenewbornone thousand daysoral healthoral microbiomepregnancyvaginal delivery

Identifiers

PMID34071058
PMCPMC8197112

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.