Evidence map›Paper›PMID 34071045›Full record

ArticleInternational journal of molecular sciences2021

Prognostic Role of Tumoral PD-L1 and IDO1 Expression, and Intratumoral CD8+ and FoxP3+ Lymphocyte Infiltrates in 132 Primary Cutaneous Merkel Cell Carcinomas.

Piotr Donizy, Cheng-Lin Wu, Janusz Kopczynski, Malgorzata Pieniazek, Przemyslaw Biecek, Janusz Ryś, Mai P Hoang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Efficacy of Immune Checkpoint Inhibitors and Oncoviruses in Solid Tumors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
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  8. CD8JCO precision oncology · 2024
    Review
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  11. Review
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  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Personalized treatment concepts in extraocular cancer.Advances in ophthalmology practice and research
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

Piotr DonizyDepartment of Clinical and Experimental Pathology, Wroclaw Medical University, 50-556 Wroclaw, Poland.ORCID 0000-0002-8729-6216
Cheng-Lin WuDepartment of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan.ORCID 0000-0002-1331-2092
Janusz KopczynskiDepartment of Surgical Pathology, Holy Cross Cancer Centre, 25-734 Kielce, Poland.
Malgorzata PieniazekDepartment of Oncology and Division of Surgical Oncology, Wroclaw Medical University, 53-413 Wroclaw, Poland.
Przemyslaw BiecekDepartment of Mathematics and Information Science, Warsaw University of Technology, 00-628 Warsaw, Poland.ORCID 0000-0001-8423-1823
Janusz RyśDepartment of Pathology, Center of Oncology, M. Sklodowska-Curie Memorial Institute, 31-115 Krakow, Poland.
Mai P HoangDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-1406-7981
Wroclaw Medical University · PLHarvard University · USHoly Cross University · PLNational Cheng Kung University Hospital · TWThe Maria Sklodowska-Curie National Research Institute of Oncology · PLWarsaw University of Technology · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The association of immune markers and clinicopathologic features and patient outcome has not been extensively studied in Merkel cell carcinoma (MCC). We correlated tumoral PD-L1 and IDO1 expression, and intratumoral CD8+ and FoxP3+ lymphocytes count with clinicopathologic variables, Merkel cell polyomavirus (MCPyV) status, and patient outcomes in a series of 132 MCC. By univariate analyses, tumoral PD-L1 expression >1% and combined tumoral PD-L1 >1% and high intratumoral FoxP3+ lymphocyte count correlated with improved overall survival (OS) (

Indexed as

Adaptive ImmunityAgedAged, 80 and overAge FactorsB7-H1 AntigenBiomarkers, TumorCarcinoma, Merkel CellCD8-Positive T-LymphocytesFemaleForkhead Transcription FactorsHead and Neck NeoplasmsHumansIndoleamine-Pyrrole 2,3,-DioxygenaseKaplan-Meier EstimateLymphocyte CountLymphocytes, Tumor-InfiltratingB7-H1 AntigenBiomarkers, TumorCD274 protein, humanForkhead Transcription FactorsFOXP3 protein, humanIDO1 protein, humanIndoleamine-Pyrrole 2,3,-DioxygenaseNeoplasm ProteinsCD8FoxP3IDO1Merkel cell carcinomaPD-L1

Identifiers

PMID34071045
PMCPMC8197111
OpenAlexW3165255814

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.