Evidence map›Paper›PMID 34071042›Full record

ArticleInternational journal of molecular sciences2021

Austalide K from the Fungus

Kwang-Jin Kim, Jusung Lee, Weihong Wang, Yongjin Lee, Eunseok Oh, Kyu-Hyung Park, Chanyoon Park, Gee-Eun Woo, Young-Jin Son, Heonjoong Kang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Metabolic bone disorders and the promise of marine osteoactive compounds.Cellular and molecular life sciences : CMLS · 2023
    Review
  8. Article
  9. Review
  10. Article
  11. Osteoclastogenesis and Osteogenesis.International journal of molecular sciences · 2022
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Kwang-Jin KimDepartment of Pharmacy, Sunchon National University, 315 Maegok-dong, Suncheon 57922, Korea.
Jusung LeeLaboratory of Marine Drugs, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Korea.
Weihong WangLaboratory of Marine Drugs, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Korea.ORCID 0000-0002-7389-635X
Yongjin LeeDepartment of Pharmacy, Sunchon National University, 315 Maegok-dong, Suncheon 57922, Korea.
Eunseok OhLaboratory of Marine Drugs, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Korea.
Kyu-Hyung ParkLaboratory of Marine Drugs, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Korea.
Chanyoon ParkInterdisciplinary Graduate Program in Genetic Engineering, Seoul National University, NS-80, Seoul 08826, Korea.
Gee-Eun WooLaboratory of Marine Drugs, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Korea.
Young-Jin SonDepartment of Pharmacy, Sunchon National University, 315 Maegok-dong, Suncheon 57922, Korea.
Heonjoong KangLaboratory of Marine Drugs, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Korea.
Seoul National University · KRSunchon National University · KR

Funding

the Basic Science Research Program funded by the Ministry of Science and ICT NRF-2019R1A2C2005492the Basic Science Research Program funded by the Ministry of Science, ICT & Future Planning NRF-2015M1A5A1037572
6 · The paper itself

Abstract

Osteoporosis is a chronic disease that has become a serious public health problem due to the associated reduction in quality of life and its increasing financial burden. It is known that inhibiting osteoclast differentiation and promoting osteoblast formation prevents osteoporosis. As there is no drug with this dual activity without clinical side effects, new alternatives are needed. Here, we demonstrate that austalide K, isolated from the marine fungus

Indexed as

AnimalsBone Density Conservation AgentsBone ResorptionCell DifferentiationDisease Models, AnimalDrug Evaluation, PreclinicalGene Expression RegulationGeologic SedimentsLipopolysaccharidesMaleMiceMice, Inbred ICRMolecular StructureNFATC Transcription FactorsOsteoblastsOsteoclastsAcp5 protein, mouseaustalide KBone Density Conservation AgentsLipopolysaccharidesNfatc1 protein, mouseNFATC Transcription FactorsRANK LigandTartrate-Resistant Acid PhosphataseTnfsf11 protein, mouseXanthenesbone diseasesbone remodelingmarine fungusosteoporosis

Identifiers

PMID34071042
PMCPMC8197085
OpenAlexW3164690208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.