Evidence map›Paper›PMID 34071037›Full record

ReviewInternational journal of molecular sciences2021

The Effect of Platelet-Rich Plasma on the Intra-Articular Microenvironment in Knee Osteoarthritis.

Dawid Szwedowski, Joanna Szczepanek, Łukasz Paczesny, Jan Zabrzyński, Maciej Gagat, Ali Mobasheri, Sławomir Jeka

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  20. Platelet-rich plasma for treatment of knee osteoarthritis: a narrative review.Frontiers in pain research (Lausanne, Switzerland) · 2026
    Review

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dawid SzwedowskiOrthopedic Arthroscopic Surgery International (O.A.S.I.) Bioresearch Foundation, Gobbi N.P.O., 20133 Milan, Italy.ORCID 0000-0002-7027-0626
Joanna SzczepanekCentre for Modern Interdisciplinary Technologies, Nicolaus Copernicus University, 87100 Torun, Poland.ORCID 0000-0002-4287-5353
Łukasz PaczesnyOrvit Clinic, Citomed Healthcare Center, 87100 Torun, Poland.ORCID 0000-0002-1706-8090
Jan ZabrzyńskiOrvit Clinic, Citomed Healthcare Center, 87100 Torun, Poland.ORCID 0000-0003-2714-2466
Maciej GagatDepartment of Histology and Embryology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85067 Bydgoszcz, Poland.ORCID 0000-0002-5445-8821
Ali MobasheriResearch Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, FI-90014 Oulu, Finland.ORCID 0000-0001-6261-1286
Sławomir JekaDepartment and Clinic of Rheumatology and Connective Tissue Diseases, University Hospital No. 2, Collegium Medicum UMK, 85168 Bydgoszcz, Poland.ORCID 0000-0003-2766-8046

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Knee osteoarthritis (KOA) represents a clinical challenge due to poor potential for spontaneous healing of cartilage lesions. Several treatment options are available for KOA, including oral nonsteroidal anti-inflammatory drugs, physical therapy, braces, activity modification, and finally operative treatment. Intra-articular (IA) injections are usually used when the non-operative treatment is not effective, and when the surgery is not yet indicated. More and more studies suggesting that IA injections are as or even more efficient and safe than NSAIDs. Recently, research to improve intra-articular homeostasis has focused on biologic adjuncts, such as platelet-rich plasma (PRP). The catabolic and inflammatory intra-articular processes that exists in knee osteoarthritis (KOA) may be influenced by the administration of PRP and its derivatives. PRP can induce a regenerative response and lead to the improvement of metabolic functions of damaged structures. However, the positive effect on chondrogenesis and proliferation of mesenchymal stem cells (MSC) is still highly controversial. Recommendations from in vitro and animal research often lead to different clinical outcomes because it is difficult to translate non-clinical study outcomes and methodology recommendations to human clinical treatment protocols. In recent years, significant progress has been made in understanding the mechanism of PRP action. In this review, we will discuss mechanisms related to inflammation and chondrogenesis in cartilage repair and regenerative processes after PRP administration in in vitro and animal studies. Furthermore, we review clinical trials of PRP efficiency in changing the OA biomarkers in knee joint.

Indexed as

Platelet-Rich PlasmaAnimalsCells, CulturedCellular MicroenvironmentChondrocytesChondrogenesisCytokinesCytoplasmic GranulesGuinea PigsHumansHyaluronic AcidImmunologic FactorsInjections, Intra-ArticularIntercellular Signaling Peptides and ProteinsNeurotransmitter AgentsOsteoarthritis, KneeCytokinesHyaluronic AcidImmunologic FactorsIntercellular Signaling Peptides and ProteinsNeurotransmitter Agentscartilage repairknee osteoarthritis (KOA)platelet-rich plasma (PRP)regenerative medicine

Identifiers

PMID34071037
PMCPMC8197096

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.