Evidence map›Paper›PMID 34071024›Full record

ReviewJournal of clinical medicine2021

Incidence of Immune-Mediated Pseudoprogression of Lymphoma Treated with Immune Checkpoint Inhibitors: Systematic Review and Meta-Analysis.

Amy Junghyun Lee, Kyung Won Kim, Young Chul Cho, Yousun Ko, Yu Sub Sung, Youngbin Shin, Jiwoo Lee, Mi-Hyun Kim

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Imaging the efficacy and side effects of CAR T-cell therapy in children and young adults.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026
    Review
  3. [Pseudoprogression after start of immunotherapy].Radiologie (Heidelberg, Germany) · 2026
    Review
  4. Review
  5. Complex immunotherapy-mediated response patterns depicted on serialAsia Oceania journal of nuclear medicine & biology · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Amy Junghyun LeeDepartment of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Kyung Won KimDepartment of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.ORCID 0000-0002-1532-5970
Young Chul ChoBiomedical Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea.
Yousun KoBiomedical Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea.
Yu Sub SungDepartment of Convergence Medicine, Clinical Research Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.ORCID 0000-0002-9215-735X
Youngbin ShinBiomedical Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea.
Jiwoo LeeDepartment of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Mi-Hyun KimDepartment of Radiation Science & Technology, Jeonbuk National University, Jeonju 54896, Korea.
Ulsan College · KRAsan Medical Center · KRJeonbuk National University · KR

Funding

National Research Foundation of Korea NRF-2020R1F1A1048267National Research Foundation of Korea NRF-2020R1F1A1076604
6 · The paper itself

Abstract

We evaluated the incidence of pseudoprogression and indeterminate response (IR) in patients with lymphoma treated with immune checkpoint inhibitors (ICIs). A systematic search of PubMed and EMBASE was performed up to 6 February 2021, using the keywords "lymphoma," "immunotherapy," and "pseudoprogression." Random-effects models were used to calculate both pooled incidence of pseudoprogression patients with lymphoma and an IR according to LYRIC criteria, while the Higgins inconsistency index (I2) test and Cochran's Q test were used for heterogeneity. Eight original articles were included, in which the number of patients ranged from 7 to 243. Among the lymphoma patients with ICIs, the pooled incidence of pseudoprogression was 10% (95% confidence interval [CI]: 0.06-0.17). There was no publication bias in Begg's test (

Indexed as

indeterminate responseLuganolymphomameta-analysispseudoprogression

Identifiers

PMID34071024
PMCPMC8197164
OpenAlexW3163998627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.