ArticleInternational journal of molecular sciences2021
Oral Microbiome in Relation to Periodontitis Severity and Systemic Inflammation.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 87 citations in OpenAlex.
- Progressive Shifts in Oral Plaque Microbiota From Health to Coronary Artery Disease and Acute Myocardial Infarction.Cardiology research · 2026Article
- Metagenomics in the Interplay Among Oral and Gut Dysbiosis.Metabolites · 2026Review
- Classification of the tongue microbiota and its associations with lifestyle factors and health status.NPJ biofilms and microbiomes · 2026Article
- Effects of Phthalate Exposure on Oral Microbiome Diversity and Enrichment of Gemella and Streptococcus.International dental journal · 2026Article
- Improving metabolic and inflammatory balance prevents periodontal complications in diabetes.World journal of diabetes · 2026Article
- The ROOT-CTRCD study: exploring the relationship of oral health to cancer therapy-related cardiac dysfunction in HER2-positive breast cancer patients.Cardio-oncology (London, England) · 2026Article
- The impact of organ transplantation on changes in the oral microbiome, particularly on bacteria causing periodontal inflammation - narrative review.Frontiers in cellular and infection microbiology · 2026Review
- From health to periodontitis: dynamic changes in the subgingival microbiome and their association with systemic inflammation levels.Frontiers in cellular and infection microbiology · 2026Article
- Oral microbiome profiles by periodontitis stage in a Korean population.Frontiers in cellular and infection microbiology · 2026Article
- Fimbriae potentiateCurrent research in microbial sciences · 2026Review
- Taxonomic and functional signatures of smoking and periodontitis severity in the subgingival microbiome of older adults.npj aging · 2025Article
- Article
- Observational
- Integrative insights into the oral microbiome's role in systemic diseases: novel therapeutic strategies and future directions.Antonie van Leeuwenhoek · 2025Review
- Continuous glucose monitoring reveals periodontitis-induced glucose variability, insulin resistance, and gut microbiota dysbiosis in mice.Scientific reports · 2025Article
- Preventive and Therapeutic Potential of Streptococcus cristatus CA119 in Experimental Periodontitis in Rats.Probiotics and antimicrobial proteins · 2025Article
- ORMCKB: A Knowledge Database for Personalized Medicine in Deciphering the Oral Microbiome-Disease Axis.Interdisciplinary sciences, computational life sciences · 2025Article
- Diet-microbiome synergy: unraveling the combined impact on frailty through interactions and mediation.Nutrition journal · 2025Article
- Microenvironment-sensitive hydrogels as promising drug delivery systems for co-encapsulating microbial homeostasis probiotics and anti-inflammatory drugs to treat periodontitis.Materials today. Bio · 2025Review
- Significant Associations Between Blood Cell Counts and Plasma Cytokines, Chemokines, and Growth Factors.International journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Systemic inflammation induced by periodontitis is suggested to be the link between periodontitis and cardiovascular disease. The aim of this work was to explore the oral microbiome in periodontitis in relation to disease severity and systemic inflammation. The saliva and subgingival microbiome from periodontal pocket samples of patients with severe (n = 12) and mild periodontitis (n = 13) were analyzed using metagenomic shotgun sequencing. The taxa and pathways abundances were quantified. The diversity was assessed and the abundances to phenotype associations were performed using ANCOM and linear regression. A panel of inflammatory markers was measured in blood and was associated with taxa abundance. The microbial diversity and species richness did not differ between severe and mild periodontitis in either saliva or periodontal pockets. However, there were significant differences in the microbial composition between severe and mild periodontitis in the subgingival microbiome (i.e., pocket samples) and, in a lower grade, in saliva, and this is positively associated with systemic inflammatory markers. The "red complex" and "cluster B" abundances in periodontal pockets were strongly associated with inflammatory markers interleukin-6 and the white blood cell count. Our data suggest that systemic inflammation in severe periodontitis may be driven by the oral microbiome and may support the indirect (inflammatory) mechanism for the association between periodontitis and cardiovascular disease.
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