Evidence map›Paper›PMID 34070884›Full record

ArticleMaterials (Basel, Switzerland)2021

δ-Lactones-A New Class of Compounds That Are Toxic to

Paweł Kowalczyk, Barbara Gawdzik, Damian Trzepizur, Mateusz Szymczak, Grzegorz Skiba, Stanisława Raj, Karol Kramkowski, Rafał Lizut, Ryszard Ostaszewski

Open access · goldAbstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Synthesis and Antimicrobial Activity of the PathogenicInternational journal of molecular sciences · 2023
    Article
  7. Aluminium(III) Oxide-The Silent Killer of Bacteria.Molecules (Basel, Switzerland) · 2023
    Article
  8. Article
  9. Article
  10. Antimicrobial Activity of Lactones.Antibiotics (Basel, Switzerland) · 2022
    Review
  11. Article
  12. Functionalised Anodised Aluminium Oxide as a Biocidal Agent.International journal of molecular sciences · 2022
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Paweł KowalczykDepartment of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland.ORCID 0000-0003-4025-3750
Barbara GawdzikInstitute of Chemistry, Jan Kochanowski University, Swietokrzyska 15 G, 25-406 Kielce, Poland.
Damian TrzepizurInstitute of Organic Chemistry PAS, Kasprzaka 44/52, 01-224 Warsaw, Poland.ORCID 0000-0001-6435-624X
Mateusz SzymczakDepartment of Molecular Virology, Institute of Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.ORCID 0000-0003-4056-7792
Grzegorz SkibaDepartment of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland.
Stanisława RajDepartment of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland.
Karol KramkowskiDepartment of Physical Chemistry, Medical University of Bialystok, Kilińskiego 1 str, 15-089 Bialystok, Poland.
Rafał LizutDepartment of Mathematics, Informatics and Landscape Architecture, Institute of Informatics, The John Paul II Catholic University of Lublin, 20-708 Lublin, Poland.ORCID 0000-0002-6067-1469
Ryszard OstaszewskiInstitute of Organic Chemistry PAS, Kasprzaka 44/52, 01-224 Warsaw, Poland.ORCID 0000-0002-3032-196X
Kielanowski Institute of Animal Physiology and Nutrition · PLInstitute of Organic Chemistry · PLJan Kochanowski University · PLJohn Paul II Catholic University of Lublin · PLMedical University of Białystok · PLUniversity of Warsaw · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lactones are among the well-known organic substances with a specific taste and smell. They are characterized by antibacterial, antiviral, anti-inflammatory, and anti-cancer properties. In recent years, among this group of compounds, new biologically active substances have been searched by modifying the main (leading) structure with new analogs with stronger or different responses that may have a toxic effect on the cells of pathogenic bacteria and constitute an alternative to commonly used antibiotics. A preliminary study of δ-lactone derivatives as new potential candidates for antibacterial drugs was conducted. Particular emphasis was placed on the selection of the structure of lactones with the highest biological activity, especially those with fluorine in their structure as a substituent in terms of action on bacterial lipopolysaccharide (LPS) in the model strains of

Indexed as

antibioticsE. coli strainslipopolysaccharideoxidative stressδ-lactones

Identifiers

PMID34070884
PMCPMC8199173
OpenAlexW3164639970

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.