Evidence map›Paper›PMID 34070861›Full record

ArticleChildren (Basel, Switzerland)2021

Further Evidence That Defects in Main Thyroid Dysgenesis-Related Genes Are an Uncommon Etiology for Primary Congenital Hypothyroidism in Mexican Patients: Report of Rare Variants in

Miguel Angel Alcántara-Ortigoza, Iraís Sánchez-Verdiguel, Liliana Fernández-Hernández, Sergio Enríquez-Flores, Aidy González-Núñez, Nancy Leticia Hernández-Martínez, Carmen Sánchez, Ariadna González-Del Angel

Open access · goldAbstract read
In one paragraph

Article in Children (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Congenital Hypothyroidism Patients With Thyroid Hormone Receptor Variants Are Not Rare: A Systematic Review.Inquiry : a journal of medical care organization, provision and financing
    Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Miguel Angel Alcántara-OrtigozaLaboratorio de Biología Molecular, Subdirección de Investigación Médica, Instituto Nacional de Pediatría, Secretaría de Salud, Ciudad de Mexico CP 04530, Mexico.ORCID 0000-0003-0592-8214
Iraís Sánchez-VerdiguelConsulta Externa, Instituto Nacional de Pediatría, Secretaría de Salud, Programa de Maestría y Doctorado en Ciencias Médicas, Odontológicas y de la Salud, UNAM, Ciudad de Mexico CP 04530, Mexico.
Liliana Fernández-HernándezLaboratorio de Biología Molecular, Subdirección de Investigación Médica, Instituto Nacional de Pediatría, Secretaría de Salud, Ciudad de Mexico CP 04530, Mexico.ORCID 0000-0002-4153-6966
Sergio Enríquez-FloresGrupo de Investigación en Biomoléculas y Salud Infantil, Laboratorio de Errores Innatos del Metabolismo y Tamiz, Instituto Nacional de Pediatría, Ciudad de Mexico CP 04530, Mexico.ORCID 0000-0003-2058-5707
Aidy González-NúñezHospital Regional Materno Infantil de Alta Especialidad de Nuevo León, Guadalupe CP 67140, Mexico.
Nancy Leticia Hernández-MartínezLaboratorio de Biología Molecular, Subdirección de Investigación Médica, Instituto Nacional de Pediatría, Secretaría de Salud, Ciudad de Mexico CP 04530, Mexico.
Carmen SánchezLaboratorio de Seguimiento del Neurodesarrollo, Instituto Nacional de Pediatría, Ciudad de Mexico CP 04530, Mexico.
Ariadna González-Del AngelLaboratorio de Biología Molecular, Subdirección de Investigación Médica, Instituto Nacional de Pediatría, Secretaría de Salud, Ciudad de Mexico CP 04530, Mexico.ORCID 0000-0002-7096-0969
Secretaria de Salud · MXInstituto Nacional de Pediatria · MXHospital Regional de Alta Especialidad del Bajío · MX

Funding

Fondo Sectorial de Investigación en Salud y Seguridad Social SS/IMSS/ISSSTE-CONACyT SALUD-2014-01-233654Instituto Nacional de Pediatria Recursos Fiscales 2015-2020, Programa E022 Investigación y Desarrollo Tecnológico en Salud
6 · The paper itself

Abstract

Mexico shows a high birth prevalence of congenital hypothyroidism (CH) due to thyroid dysgenesis (TD).

Indexed as

congenital hypothyroidismFOXE1Mexican populationmultiplex ligation-dependent probe amplification (MLPA)NKX2-1NKX2-5PAX8polyalanine tractprotein modelingthyroid dysgenesisTSH receptor

Identifiers

PMID34070861
PMCPMC8227333
OpenAlexW3164528120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.