Evidence map›Paper›PMID 34070839›Full record

ArticleInternational journal of molecular sciences2021

Naoki Kawahara, Yuki Yamada, Hiroshi Kobayashi

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Molecular Biology of Human Fertility: Stepping towards a Tailored Approach.International journal of molecular sciences · 2022
    Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Naoki KawaharaDepartment of Obstetrics and Gynecology, Nara Medical University, Nara 634-8521, Japan.ORCID 0000-0003-1154-2481
Yuki YamadaDepartment of Obstetrics and Gynecology, Nara Medical University, Nara 634-8521, Japan.
Hiroshi KobayashiDepartment of Obstetrics and Gynecology, Nara Medical University, Nara 634-8521, Japan.
Nara Medical University · JP

Funding

JSPS KAKENHI 16K11150JSPS KAKENHI 18K09234JSPS KAKENHI 18K09235JSPS KAKENHI 18K09269JSPS KAKENHI 19K09809
6 · The paper itself

Abstract

backgroundOvarian clear cell carcinoma (OCCC) is resistant to platinum chemotherapy and is characterized by poor prognosis. Today, the use of poly (ADP-ribose) polymerase (PARP) inhibitor, which is based on synthetic lethality strategy and characterized by cancer selectivity, is widely used for new types of molecular-targeted treatment of relapsed platinum-sensitive ovarian cancer. However, it is less effective against OCCC.

methodsWe conducted siRNA screening to identify synthetic lethal candidates for the

resultsLoss of

conclusionThis study showed for the first time that

Indexed as

Synthetic Lethal MutationsAdenocarcinoma, Clear CellAnimalsAntineoplastic AgentsApoptosisCell CycleCell Line, TumorCell ProliferationCisplatinCyclin EDNA-Binding ProteinsFemaleGene Expression Regulation, NeoplasticHumansMiceMice, NudeAntineoplastic AgentsARID1A protein, humanCCNE1 protein, humanCisplatinCyclin EDNA-Binding ProteinsOncogene ProteinsRNA, Small InterferingTranscription FactorsARID1A mutationCyclin-E1ovarian clear cell carcinomasynthetic lethality

Identifiers

PMID34070839
PMCPMC8198755
OpenAlexW3164432668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.