Evidence map›Paper›PMID 34070785›Full record

ReviewInternational journal of molecular sciences2021

Somatostatin, a Presynaptic Modulator of Glutamatergic Signal in the Central Nervous System.

Anna Pittaluga, Alessandra Roggeri, Giulia Vallarino, Guendalina Olivero

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Systematic review and meta-analysis of bulk RNAseq studies in human Alzheimer's disease brain tissue.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Pooled it
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  10. Pathogenesis of Dementia.International journal of molecular sciences · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Anna PittalugaDepartment of Pharmacy, School of Medical and Pharmaceutical Sciences, University of Genova, 16148 Genova, Italy.ORCID 0000-0002-4011-1165
Alessandra RoggeriDepartment of Pharmacy, School of Medical and Pharmaceutical Sciences, University of Genova, 16148 Genova, Italy.
Giulia VallarinoDepartment of Pharmacy, School of Medical and Pharmaceutical Sciences, University of Genova, 16148 Genova, Italy.
Guendalina OliveroDepartment of Pharmacy, School of Medical and Pharmaceutical Sciences, University of Genova, 16148 Genova, Italy.
University of Genoa · ITOspedale Policlinico San Martino · IT

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca 201779W93T_004.
6 · The paper itself

Abstract

Somatostatin is widely diffused in the central nervous system, where it participates to control the efficiency of synaptic transmission. This peptide mainly colocalizes with GABA, in inhibitory, GABA-containing interneurons from which it is actively released in a Ca

Indexed as

AnimalsCalciumCentral Nervous SystemCyclic AMPGene Expression RegulationGlutamic AcidHumansInterneuronsNeuronsPotassiumReceptors, Metabotropic GlutamateReceptors, N-Methyl-D-AspartateReceptors, SomatostatinSomatostatinSynapsesSynaptic TransmissionCalciumCyclic AMPGlutamic AcidPotassiumReceptors, Metabotropic GlutamateReceptors, N-Methyl-D-AspartateReceptors, SomatostatinSomatostatinglutamatemetamodulationNMDA receptorsnoradrenalinesomatostatinsst2 receptorssst5 receptorsvolume diffusion

Identifiers

PMID34070785
PMCPMC8198526
OpenAlexW3165370765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.