ReviewAntioxidants (Basel, Switzerland)2021
Coenzyme Q10 and Male Infertility: A Systematic Review.
Review in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06342856 (Evaluation of Treatment With Coenzyme Q10 and L-Carnitine on Semen Parameters in Infertile Men With Idiopathic Oligoasthenoteratospermia a Placebo Controlled Clinical Trial), which is not on this map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Treatment With Coenzyme Q10 and L-Carnitine on Semen Parameters in Infertile Men With Idiopathic Oligoasthenoteratospermia a Placebo Controlled Clinical Trial
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Association between body mass index and semen quality: a systematic review and meta-analysis.International journal of obesity (2005) · 2024Pooled it
- Pooled it
- Impact of coenzyme Q10 as an adjuvant therapy to letrozole on spermiogram results and sex hormone levels in Iraqi men with infertility; randomized open label comparative study.F1000Research · 2023Trial
- Efficacy and Safety of Coenzyme Q10 in Idiopathic Male Infertility: A Systematic Review and Meta-Analysis of Randomized Trials.The world journal of men's health · 2026Article
- Reactive Oxygen and Nitrogen Species in Male Reproductive Health: From Molecular Mechanisms to Clinical Consequences.Antioxidants (Basel, Switzerland) · 2026Review
- Nutritional modulation of male fertility: a molecular-focused scoping review.Journal of health, population, and nutrition · 2026Article
- Inflammaging: Immune-Metabolic Crosstalk Between the Prostate-Testis and Musculoskeletal System.International journal of molecular sciences · 2026Review
- Does coenzyme Q10 protect testicular function and spermatogenesis in rats receiving levofloxacin-containing therapy?Clinical and experimental reproductive medicine · 2026Article
- Role of coenzyme Q10 on some physiological aspects of male rat exposure to silicon dioxide nanoparticles.Open veterinary journal · 2026Article
- Impact of antioxidant and micronutrient intake on varicocele-associated infertility: a retrospective analysis.Frontiers in nutrition · 2026Article
- The aging male: impact of aging on male reproduction.Biogerontology · 2025Review
- The Role of Antioxidants in Male Fertility: A Comprehensive Review of Mechanisms and Clinical Applications.Antioxidants (Basel, Switzerland) · 2025Review
- A Narrative Review of Heavy Metals and Sperm Quality: The Interplay with Antioxidant Imbalance and Reactive Oxygen Species.Current issues in molecular biology · 2025Review
- Effects of coenzyme Q10 on sperm parameters and pathological changes induced by Wi-Fi waves in the testicular tissue of rats.Annals of medicine and surgery (2012) · 2025Article
- Comparative Analysis of Classic Semen Extenders for Frozen-Thawed Boar Semen.Animals : an open access journal from MDPI · 2025Article
- Platelet Mitochondrial Function and Endogenous Coenzyme QInternational journal of molecular sciences · 2024Article
- Comparison of Protective Effect of Tri-circulator and Coenzyme Q10 on Myocardial Injury and the Mechanism Study by Zebrafish Model.Cardiovascular toxicology · 2024Article
- Gender Disparities in Health Biomarkers, Lifestyle Patterns, and Nutritional Status among Bank Staff: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2024Article
- Oxidative Stress and Male Infertility: The Protective Role of Antioxidants.Medicina (Kaunas, Lithuania) · 2023Review
- COVID-19 and Male Infertility: Is There a Role for Antioxidants?Antioxidants (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infertility affects 15% of couples worldwide. A male factor is involved in 50% of cases. The etiology of male infertility is poorly understood, but there is evidence for a strong association between oxidative stress (OS) and poor seminal fluid quality. For this reason, therapy with antioxidants is one of the cornerstones of empirical treatment of male infertility. Coenzyme Q10 (CoQ10)-an essential cofactor for energy production with major antioxidant properties-is commonly used to support spermatogenesis in idiopathic male infertility. This systematic review aims to elucidate the usefulness of CoQ10 supplementation in the treatment of male infertility, particularly with regard to semen quality assessed by conventional and advanced methods, and pregnancy rates. All studies report a beneficial effect of CoQ10 supplementation on semen parameters, although randomized controlled trials are a minority. Moreover, the optimal dosage of CoQ10 or how it can be combined with other antioxidant molecules to maximize its effect is unknown. However, CoQ10 is still one of the most promising molecules to treat idiopathic male infertility and warrants further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.