Evidence map›Paper›PMID 34070744›Full record

ArticleInternational journal of molecular sciences2021

Regulation of ClC-2 Chloride Channel Proteostasis by Molecular Chaperones: Correction of Leukodystrophy-Associated Defect.

Ssu-Ju Fu, Meng-Chun Hu, Cheng-Tsung Hsiao, An-Ting Cheng, Tsung-Yu Chen, Chung-Jiuan Jeng, Chih-Yung Tang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Restoration of Shal/KCellular and molecular life sciences : CMLS · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ssu-Ju FuDepartment of Physiology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.
Meng-Chun HuDepartment of Physiology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.
Cheng-Tsung HsiaoDepartment of Physiology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.
An-Ting ChengDepartment of Physiology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.
Tsung-Yu ChenCenter for Neuroscience and Department of Neurology, University of California, Davis, CA 95616, USA.
Chung-Jiuan JengInstitute of Anatomy and Cell Biology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 12212, Taiwan.
Chih-Yung TangDepartment of Physiology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.ORCID 0000-0003-1065-2865
National Taiwan University · TWNational Yang Ming Chiao Tung University · TWUniversity of California, Davis · US

Funding

Molecular Physiology of CLC Chloride ChannelsR01GM065447 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI CHEN, TSUNG-YU · 2003 to 2018
$3.9M
Ministry of Science and Technology, Taiwan 108-2320-B-002-033-MY3Ministry of Science and Technology, Taiwan 108-2320-B-010-039-MY3NIH HHS R01GM065447
6 · The paper itself

Abstract

The ClC-2 channel plays a critical role in maintaining ion homeostasis in the brain and the testis. Loss-of-function mutations in the ClC-2-encoding human

Indexed as

AnimalsBenzoquinonesBrainChloride ChannelsCHO CellsCLC-2 Chloride ChannelsCricetulusDisease Models, AnimalEndoplasmic Reticulum-Associated DegradationGene Expression RegulationHEK293 CellsHSP70 Heat-Shock ProteinsHSP90 Heat-Shock ProteinsHumansLactams, MacrocyclicLeydig CellsAhsa1 protein, mouseBenzoquinonesChloride ChannelsCLC-2 Chloride ChannelsClcn2 protein, mouseFkbp8 protein, mouseHSP70 Heat-Shock ProteinsHsp90b1 protein, mouseHSP90 Heat-Shock ProteinsLactams, MacrocyclicMolecular ChaperonesProtein IsoformsTacrolimus Binding Proteinstanespimycin17-AAGchannelopathychaperoneco-chaperoneprotein quality controlproteostasis

Identifiers

PMID34070744
PMCPMC8197790
OpenAlexW3164470595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.