ReviewJournal of clinical medicine2021
Safety, Efficacy, and Outcomes of N-Butyl Cyanoacrylate Glue Injection through the Endoscopic or Radiologic Route for Variceal Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis.
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Clip-first emergency hemostasis for acute esophagogastric variceal bleeding: a retrospective comparative study.Surgical endoscopy · 2026Article
- Safety and Efficacy of Vascular Embolization with N-Butyl Cyanoacrylate-Lipiodol Mixture: A Systematic Literature Review and Meta-Analysis of 8996 Patients.Cardiovascular and interventional radiology · 2026Review
- Endoscopic salvage of a N-butyl cyanoacrylate-occluded gastroscope using cholangioscopic electrohydraulic lithotripsy.Endoscopy · 2026Article
- Mechanical Thrombectomy for N-butyl-2 Cyanoacrylate Cerebral Embolism via Portopulmonary Venous Anastomosis Following Endoscopic Injection Sclerotherapy: A Case Report.NMC case report journal · 2025Article
- Endoscopic Variceal Therapy With Multisystemic Glue Embolism: A Case Report and Narrative Review of a Rare but Severe Complication.Case reports in critical care · 2025Article
- Cyanoacrylate injection for hemorrhagic giant esophageal varices: simultaneous disappearance of the varices with hemostasis.Endoscopy · 2024Article
- Trans-splenic percutaneous glue embolization of bleeding gastric varices in the setting of malignant sinistral portal hypertension.CVIR endovascular · 2024Article
- How I Do It: Endovascular Management of Acute Nonvariceal Gastrointestinal Bleeding.Seminars in interventional radiology · 2023Review
- Endoscopic ultrasound-guided diagnosis and treatment of gastric varices.World journal of gastrointestinal endoscopy · 2022Review
- The role of endoscopic ultrasound for portal hypertension in liver cirrhosis.Journal of medical ultrasonics (2001) · 2022Review
- Modified endoscopic ultrasound-guided selective N-butyl-2-cyanoacrylate injections for gastric variceal hemorrhage in left-sided portal hypertension: A case report.World journal of clinical cases · 2022Article
- NBCA-Lipiodol Mixture Embolization of Persistent Urine Leakage After Orthotopic Neobladder Formation: Techniques and Outcomes.Frontiers in surgery · 2022Article
- Efficacy and Safety of N-Butyl 2 Cyanoacrylate Injection for Treatment of Gastric Varices: A five year experience from a tertiary care hospital in Karachi, Pakistan.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We performed a systematic review and meta-analysis of published studies to assess the efficacy, safety, and outcomes of N-butyl cyanoacrylate (NBCA) injection for the treatment of variceal gastrointestinal bleeding (GIB). The MEDLINE/PubMed, EMBASE, and SCOPUS databases were searched for English-language studies published from January 1980 to December 2019 and including patients who had injection of NBCA for variceal GIB. Two independent reviewers extracted and evaluated the data from eligible studies. Exclusion criteria were sample size < 5, article reporting the use of NBCA with other embolic agents, no extractable data, and duplicate reports. NBCA was injected during endoscopy in 42 studies and through a direct percutaneous approach for stomal varices in 1 study. The study's endpoints were: Technical success, 30-day rebleeding, and 30-day overall and major complications. The estimated overall rates were computed with 95% confidence intervals, based on each study rate, weighted by the number of patients involved in each study. In total, 43 studies with 3484 patients were included. The technical success rate was 94.1% (95% CI: 91.6-96.1%), the 30-day rebleeding rate was 24.2% (18.9-29.9%), and 30-day overall and major complications occurred in 15.9% (11.2-21.3%) and 5.3% (3.3-7.8%) of patients, respectively. For treating variceal GIB, NBCA injection is a safe and effective method that demonstrates high technical success rate and very low major complication rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.