Evidence map›Paper›PMID 34070524›Full record

ArticleViruses2021

Noble Metal Organometallic Complexes Display Antiviral Activity against SARS-CoV-2.

Christina Chuong, Christine M DuChane, Emily M Webb, Pallavi Rai, Jeffrey M Marano, Chad M Bernier, Joseph S Merola, James Weger-Lucarelli

Abstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Metallo-antiviral aspirants:European journal of medicinal chemistry reports · 2023
    Review
  7. Article
  8. Half-Sandwich Type Platinum-Group Metal Complexes ofMolecules (Basel, Switzerland) · 2023
    Article
  9. Review
  10. Article
  11. Pharmaceuticals (Basel, Switzerland) · 2022
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christina ChuongDepartment of Biomedical Sciences and Pathobiology, Virginia Tech, VA-MD Regional College of Veterinary Medicine, Blacksburg, VA 24061, USA.
Christine M DuChaneDepartment of Chemistry, Virginia Tech, Blacksburg, VA 24061, USA.ORCID 0000-0001-9575-3424
Emily M WebbDepartment of Entomology, Virginia Tech, Blacksburg, VA 24061, USA.
Pallavi RaiDepartment of Biomedical Sciences and Pathobiology, Virginia Tech, VA-MD Regional College of Veterinary Medicine, Blacksburg, VA 24061, USA.
Jeffrey M MaranoDepartment of Translational Biology, Medicine, and Health, Virginia Tech, Blacksburg, VA 24061, USA.ORCID 0000-0003-3703-3423
Chad M BernierDepartment of Chemistry, Virginia Tech, Blacksburg, VA 24061, USA.ORCID 0000-0002-2829-865X
Joseph S MerolaDepartment of Chemistry, Virginia Tech, Blacksburg, VA 24061, USA.ORCID 0000-0002-1743-1777
James Weger-LucarelliDepartment of Biomedical Sciences and Pathobiology, Virginia Tech, VA-MD Regional College of Veterinary Medicine, Blacksburg, VA 24061, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2 emerged in 2019 as a devastating viral pathogen with no available preventative or treatment to control what led to the current global pandemic. The continued spread of the virus and increasing death toll necessitate the development of effective antiviral treatments to combat this virus. To this end, we evaluated a new class of organometallic complexes as potential antivirals. Our findings demonstrate that two pentamethylcyclopentadienyl (Cp*) rhodium piano stool complexes, Cp*Rh(1,3-dicyclohexylimidazol-2-ylidene)Cl

Indexed as

AnimalsAntiviral AgentsCell LineCell SurvivalChlorocebus aethiopsCOVID-19Dose-Response Relationship, DrugHumansMolecular StructureOrganometallic CompoundsSARS-CoV-2Vero CellsVirus ReplicationAntiviral AgentsOrganometallic CompoundsantiviralCOVID-19metallodrugsorganometallicsSARS-CoV-2virucidal

Identifiers

PMID34070524
PMCPMC8227008

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.