SynthesisMolecules (Basel, Switzerland)2021
Application of Propolis in Protecting Skeletal and Periodontal Health-A Systematic Review.
Synthesis in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- The impact of propolis-silver nanoparticles coated sutures versus conventional sutures on early intraoral wound healing in healthy and diabetic rats: a preliminary histological study.The Saudi dental journal · 2026Article
- Time-based assessment of local propolis delivery on mid-palatal suture bone formation after rapid maxillary expansion in albino rats.Odontology · 2026Article
- Propolis nanoemulsion and mesenchymal stem cell conditioned medium promote osteoblastogenesis against lipopolysaccharide-induced osteolysis in hyperglycemic rats.Scientific reports · 2026Article
- Thermoresponsive propolis gel for gingival wound healing post-depigmentation: A prospective clinical study.Journal of Taibah University Medical Sciences · 2026Article
- Effects of Cannabidiol on Bone Health: A Comprehensive Scoping Review.Biomedicines · 2026Review
- Propolis-xenograft scaffolds: comparing delivery methods for tibial bone regeneration in rats.Biomaterial investigations in dentistry · 2026Article
- Investigation of the relationship between apical periodontitis and host modulation provided by nutritional supplement: a study in rats.BMC oral health · 2025Article
- Bioactive Compounds from Propolis on Bone Homeostasis: A Narrative Review.Antioxidants (Basel, Switzerland) · 2025Review
- Propolis in Dental Implantology: A Systematic Review of Its Effects and Benefits.Journal of functional biomaterials · 2024Review
- Effects of systemic Anatolian propolis administration on a rat-irradiated osteoradionecrosis model.Journal of applied oral science : revista FOB · 2023Article
- Host Response Modulation Therapy in the Diabetes Mellitus-Periodontitis Conjuncture: A Narrative Review.Pharmaceutics · 2022Review
- Efficacy of Antioxidant Supplementation to Non-Surgical Periodontal Therapy on Metabolic Control in Type 2 Diabetes Patients: A Network Meta-Analysis.Antioxidants (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Chronic inflammation and oxidative stress are two major mechanisms leading to the imbalance between bone resorption and bone formation rate, and subsequently, bone loss. Thus, functional foods and dietary compounds with antioxidant and anti-inflammatory could protect skeletal health. This review aims to examine the current evidence on the skeletal protective effects of propolis, a resin produced by bees, known to possess antioxidant and anti-inflammatory activities. A literature search was performed using Pubmed, Scopus, and Web of Science to identify studies on the effects of propolis on bone health. The search string used was (i) propolis AND (ii) (bone OR osteoporosis OR osteoblasts OR osteoclasts OR osteocytes). Eighteen studies were included in the current review. The available experimental studies demonstrated that propolis could prevent bone loss due to periodontitis, dental implantitis, and diabetes in animals. Combined with synthetic and natural grafts, it could also promote fracture healing. Propolis protects bone health by inhibiting osteoclastogenesis and promoting osteoblastogenesis, partly through its antioxidant and anti-inflammatory actions. Despite the promising preclinical results, the skeletal protective effects of propolis are yet to be proven in human studies. This research gap should be bridged before nutraceuticals based on propolis with specific health claims can be developed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.