Evidence map›Paper›PMID 34070326›Full record

ArticleNanomaterials (Basel, Switzerland)2021

Diamond Nanoparticles-Porphyrin mTHPP Conjugate as Photosensitizing Platform: Cytotoxicity and Antibacterial Activity.

Carolina Ramos Hurtado, Gabriela Ramos Hurtado, Gabrielle Lupeti de Cena, Rafaela Campos Queiroz, Alexandre Vieira Silva, Milton Faria Diniz, Verônica Ribeiro Dos Santos, Vladimir Trava-Airoldi, Maurício da Silva Baptista, Ncediwe Tsolekile and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 3 countries.

Carolina Ramos HurtadoFederal Institute of São Paulo (IFSP), São José dos Campos 12223-201, São Paulo, Brazil.ORCID 0000-0001-9357-6305
Gabriela Ramos HurtadoInstitute of Science and Technology, São Paulo State University (UNESP), São José dos Campos 12247-004, São Paulo, Brazil.
Gabrielle Lupeti de CenaPeptide Biochemistry Laboratory, Institute of Science and Technology, Federal University of São Paulo (UNIFESP), São José dos Campos 12231-280, São Paulo, Brazil.
Rafaela Campos QueirozFederal Institute of São Paulo (IFSP), São José dos Campos 12223-201, São Paulo, Brazil.
Alexandre Vieira SilvaInstitute of Medicinal Chemistry, Helmholtz Zentrum München, 30167 Hanover, Germany.
Milton Faria DinizFundamental Sciences Division, Technological Institute of Aeronautics (ITA), São José dos Campos 12228-900, São Paulo, Brazil.
Verônica Ribeiro Dos SantosBioceramics Laboratory, Institute of Science and Technology, Federal University of São Paulo (UNIFESP), São José dos Campos 12231-280, São Paulo, Brazil.
Vladimir Trava-AiroldiSensors and Materials Associated Laboratory, National Institute for Space Research (INPE), São José dos Campos 12227-010, São Paulo, Brazil.
Maurício da Silva BaptistaDepartment of Biochemistry, Institute of Chemistry, University of São Paulo (USP), São Paulo 05508-000, São Paulo, Brazil.ORCID 0000-0001-7079-7666
Ncediwe TsolekileDepartment of Chemical Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, South Africa.
Oluwatobi Samuel OluwafemiDepartment of Chemical Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, South Africa.
Katia ConceiçãoPeptide Biochemistry Laboratory, Institute of Science and Technology, Federal University of São Paulo (UNIFESP), São José dos Campos 12231-280, São Paulo, Brazil.
Dayane Batista TadaNanomaterials and Nanotoxicology Laboratory, Institute of Science and Technology, Federal University of São Paulo (UNIFESP), São José dos Campos 12231-280, São Paulo, Brazil.
Universidade Federal de São Paulo · BRFederal Institute of São Paulo · BRUniversity of Johannesburg · ZAHelmholtz Zentrum München · DEInstituto Nacional de Pesquisas Espaciais · BRInstituto Tecnológico de Aeronáutica · BRUniversidade de São Paulo · BRUniversidade Estadual Paulista (Unesp) · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/01697-6Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/09737-2Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/20111-8
6 · The paper itself

Abstract

Conjugation of photosensitizers (PS) with nanoparticles has been largely used as a strategy to stabilize PS in the biological medium resulting in photosensitizing nanoparticles of enhanced photoactivity. Herein, (Meso-5, 10, 15, 20-tetrakis (3-hydroxyphenyl) phorphyryn (mTHPP) was conjugated with diamond nanoparticles (ND) by covalent bond. Nanoconjugate ND-mTHPP showed suitable stability in aqueous suspension with 58 nm of hydrodynamic diameter and Zeta potential of -23 mV. The antibacterial activity of ND-mTHPP was evaluated against

Indexed as

drug-resistancenanoconjugatephotodynamic antimicrobial therapy (aPDT)photosensitizers (PS)

Identifiers

PMID34070326
PMCPMC8227420
OpenAlexW3165150897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.