Evidence map›Paper›PMID 34070268›Full record

ReviewCells2021

The Orai1-AC8 Interplay: How Breast Cancer Cells Escape from Orai1 Channel Inactivation.

José Sánchez-Collado, José J López, Juan A Rosado

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Store-operated calcium entry-based targets for novel cancer therapeutic development.The Journal of pharmacology and experimental therapeutics · 2025
    Review
  3. SOCE as a regulator of neuronal activity.The Journal of physiology · 2024
    Review
  4. Physiological functions of calcium signaling via Orai1 in cancer.The journal of physiological sciences : JPS · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

José Sánchez-ColladoCellular Physiology Research Group, Department of Physiology, Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, Spain.
José J LópezCellular Physiology Research Group, Department of Physiology, Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, Spain.ORCID 0000-0002-5234-1478
Juan A RosadoCellular Physiology Research Group, Department of Physiology, Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, Spain.ORCID 0000-0002-9749-2325
Universidad de Extremadura · ES

Funding

Consejería de Educación y Empleo, Junta de Extremadura GR18061Consejería de Educación y Empleo, Junta de Extremadura IB16046Consejería de Educación y Empleo, Junta de Extremadura TA18011Ministerio de Ciencia e Innovación Grant BFU2016-74932-C2Ministerio de Ciencia e Innovación PID2019-104084GB-C21
6 · The paper itself

Abstract

The interplay between the Ca

Indexed as

Adenylyl CyclasesCalciumCalcium ChannelsFemaleHumansORAI1 ProteinTriple Negative Breast Neoplasmsadenylyl cyclase 8Adenylyl CyclasesCalciumCalcium ChannelsORAI1 ProteinORAI1 protein, humanAC8inactivationOrai1SOCEtriple-negative breast cancer cells

Identifiers

PMID34070268
PMCPMC8225208
OpenAlexW3165408208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.