Evidence map›Paper›PMID 34070214›Full record

ArticleInternational journal of molecular sciences2021

A Keratin 7 and E-Cadherin Signature Is Highly Predictive of Tubo-Ovarian High-Grade Serous Carcinoma Prognosis.

Laudine Communal, Noemi Roy, Maxime Cahuzac, Kurosh Rahimi, Martin Köbel, Diane M Provencher, Anne-Marie Mes-Masson

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  3. PANoptosis subtypes predict prognosis and immune efficacy in gastric cancer.Apoptosis : an international journal on programmed cell death · 2024
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  12. High expression of theAnnals of translational medicine · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Laudine CommunalInstitut du Cancer de Montréal, Montreal, QC H2X 0A9, Canada.ORCID 0000-0002-0651-944X
Noemi RoyInstitut du Cancer de Montréal, Montreal, QC H2X 0A9, Canada.
Maxime CahuzacInstitut du Cancer de Montréal, Montreal, QC H2X 0A9, Canada.ORCID 0000-0002-5395-8090
Kurosh RahimiInstitut du Cancer de Montréal, Montreal, QC H2X 0A9, Canada.
Martin KöbelDepartment of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada.
Diane M ProvencherInstitut du Cancer de Montréal, Montreal, QC H2X 0A9, Canada.
Anne-Marie Mes-MassonInstitut du Cancer de Montréal, Montreal, QC H2X 0A9, Canada.ORCID 0000-0002-6498-266X
Centre Hospitalier de l’Université de Montréal · CAUniversity of Calgary · CA

Funding

Canadian Institute for Health Research CIHR MOP142724Fond de recherche Québec - Santé Post-doctoral fellowship
6 · The paper itself

Abstract

During tubo-ovarian high-grade serous carcinoma (HGSC) progression, tumoral cells undergo phenotypic changes in their epithelial marker profiles, which are essential for dissemination processes. Here, we set out to determine whether standard epithelial markers can predict HGSC patient prognosis. Levels of E-CADH, KRT7, KRT18, KRT19 were quantified in 18 HGSC cell lines by Western blot and in a Discovery cohort tissue microarray (TMA) (

Indexed as

AdultAgedAged, 80 and overAntigens, CDBiomarkers, TumorBreast NeoplasmsCadherinsCarcinoma, Non-Small-Cell LungCell Line, TumorCohort StudiesCystadenocarcinoma, SerousFallopian Tube NeoplasmsFemaleHumansKaplan-Meier EstimateKeratin-19Antigens, CDBiomarkers, TumorCadherinsCDH1 protein, humanKeratin-19Keratin-7KRT19 protein, humanKRT7 protein, humanVimentinVIM protein, humanE-Cadherin/Cadherin 1/E-CADH/CDH1epithelial to mesenchymal transitionepithelial tubo-ovarian high-grade serous carcinomaKeratin 7/Cytokeratin 7/KRT7/CK7predictive biomarkerprognosis biomarker

Identifiers

PMID34070214
PMCPMC8158692
OpenAlexW3161110420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.