Evidence map›Paper›PMID 34070179›Full record

ReviewMolecules (Basel, Switzerland)2021

Conifers Phytochemicals: A Valuable Forest with Therapeutic Potential.

Kanchan Bhardwaj, Ana Sanches Silva, Maria Atanassova, Rohit Sharma, Eugenie Nepovimova, Kamil Musilek, Ruchi Sharma, Mousa A Alghuthaymi, Daljeet Singh Dhanjal, Marcello Nicoletti and 5 more

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Chemical Composition Analysis of Sea Buckthorn (Food science & nutrition · 2025
    Article
  7. Stilbene Glycosides inPlants (Basel, Switzerland) · 2025
    Article
  8. Review
  9. Ethnopharmacology ofFrontiers in pharmacology · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. AnPathogens (Basel, Switzerland) · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 6 countries.

Kanchan BhardwajSchool of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, India.ORCID 0000-0002-1708-6395
Ana Sanches SilvaNational Institute for Agricultural and Veterinary Research (INIAV), I.P., Vairão, 4485-655 Vila do Conde, Portugal.ORCID 0000-0002-0226-921X
Maria AtanassovaScientific Consulting, Chemical Engineering, University of Chemical Technology and Metallurgy, 1734 Sofia, Bulgaria.
Rohit SharmaDepartment of Rasashastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.ORCID 0000-0002-3682-3573
Eugenie NepovimovaDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech Republic.
Kamil MusilekDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech Republic.ORCID 0000-0002-7504-4062
Ruchi SharmaSchool of Bioengineering & Food Technology, Shoolini University of Biotechnology and Management Sciences, Solan 173229, India.ORCID 0000-0001-7204-9426
Mousa A AlghuthaymiBiology Department, Science and Humanities College, Shaqra University, Alquwayiyah 11971, Saudi Arabia.
Daljeet Singh DhanjalSchool of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, India.ORCID 0000-0003-4791-7388
Marcello NicolettiDepartment of Environmental Biology, Sapienza University of Rome, Square Aldo Moro, 5, 00185 Rome, Italy.
Bechan SharmaDepartment of Biochemistry, University of Allahabad, Allahabad 211002, India.ORCID 0000-0002-7835-9406
Navneet Kumar UpadhyaySchool of Pharmaceutical Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, India.ORCID 0000-0003-3030-2459
Natália Cruz-MartinsFaculty of Medicine, University of Porto, 4200-319 Porto, Portugal.ORCID 0000-0002-5934-5201
Prerna BhardwajSchool of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, India.
Kamil KučaDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech Republic.ORCID 0000-0001-9664-1109
Shoolini University · INUniversity of Hradec Králové · CZUniversidade do Porto · PTLovely Professional University · INSapienza University of Rome · ITShaqra University · SAUniversity of Allahabad · INUniversity of Chemical Technology and Metallurgy · BG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conifers have long been recognized for their therapeutic potential in different disorders. Alkaloids, terpenes and polyphenols are the most abundant naturally occurring phytochemicals in these plants. Here, we provide an overview of the phytochemistry and related commercial products obtained from conifers. The pharmacological actions of different phytochemicals present in conifers against bacterial and fungal infections, cancer, diabetes and cardiovascular diseases are also reviewed. Data obtained from experimental and clinical studies performed to date clearly underline that such compounds exert promising antioxidant effects, being able to inhibit cell damage, cancer growth, inflammation and the onset of neurodegenerative diseases. Therefore, an attempt has been made with the intent to highlight the importance of conifer-derived extracts for pharmacological purposes, with the support of relevant in vitro and in vivo experimental data. In short, this review comprehends the information published to date related to conifers' phytochemicals and illustrates their potential role as drugs.

Indexed as

ForestsAnimalsClinical Trials as TopicHumansNeuroprotectionPhytochemicalsPlant ExtractsTracheophytaPhytochemicalsPlant Extractsantibacterialanticanceranti-inflammatoryconifersneurodegenerativeoxidative stressphytoconstituent

Identifiers

PMID34070179
PMCPMC8158490
OpenAlexW3160794071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.