Evidence map›Paper›PMID 34070157›Full record

ReviewMolecules (Basel, Switzerland)2021

Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments.

Rusin Zhao, Ruijia Yang, Paul R Cooper, Zohaib Khurshid, Amin Shavandi, Jithendra Ratnayake

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06625528 (The Efficacy of Lyophilized Platelet-Rich Fibrin in Treatment of Periodontal Intra-Bony Defects), which is not on this map. Cited by 293 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
293citing papers in PubMed, 9 pooled it
32.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06625528 early_phase1active not recruitingnot on this mapstarted 2023, after this paper: background citation

The Efficacy of Lyophilized Platelet-Rich Fibrin in Treatment of Periodontal Intra-Bony Defects (A Comparative Clinical, Radiographic and Biochemical Study)

TypeinterventionalSponsorAl-Azhar UniversityRan2023 to 2025Enrolled36ConditionsTreatment of Periodontal Intra-bony DefectsArmsopen flap debridement
3 · Its place in the literature

Who cites it

293 citing papers in PubMed, 9 syntheses or guidelines pooled it, 571 citations in OpenAlex.

  1. [Evidence-based clinical analysis of tissue regeneration in endodontic microsurgery].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026
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233 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Rusin ZhaoDepartment of Oral Science, Faculty of Dentistry, University of Otago, 310 Great King Street, Dunedin 9016, New Zealand.ORCID 0000-0003-4856-6540
Ruijia YangDepartment of Oral Science, Faculty of Dentistry, University of Otago, 310 Great King Street, Dunedin 9016, New Zealand.
Paul R CooperDepartment of Oral Science, Faculty of Dentistry, University of Otago, 310 Great King Street, Dunedin 9016, New Zealand.
Zohaib KhurshidDepartment of Prosthodontics and Dental Implantology, College of Dentistry, King Faisal University, Al-Ahsa 31982, Saudi Arabia.ORCID 0000-0001-7998-7335
Amin ShavandiBioMatter Unit-École Polytechnique de Bruxelles, Université Libre de Bruxelles (ULB), Avenue F.D. Roosevelt, 50-CP 165/61, 1050 Brussels, Belgium.ORCID 0000-0002-0188-3090
Jithendra RatnayakeDepartment of Oral Science, Faculty of Dentistry, University of Otago, 310 Great King Street, Dunedin 9016, New Zealand.ORCID 0000-0002-8534-4472
University of Otago · NZKing Faisal University · SAUniversité Libre de Bruxelles · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

After tooth loss, bone resorption is irreversible, leaving the area without adequate bone volume for successful implant treatment. Bone grafting is the only solution to reverse dental bone loss and is a well-accepted procedure required in one in every four dental implants. Research and development in materials, design and fabrication technologies have expanded over the years to achieve successful and long-lasting dental implants for tooth substitution. This review will critically present the various dental bone graft and substitute materials that have been used to achieve a successful dental implant. The article also reviews the properties of dental bone grafts and various dental bone substitutes that have been studied or are currently available commercially. The various classifications of bone grafts and substitutes, including natural and synthetic materials, are critically presented, and available commercial products in each category are discussed. Different bone substitute materials, including metals, ceramics, polymers, or their combinations, and their chemical, physical, and biocompatibility properties are explored. Limitations of the available materials are presented, and areas which require further research and development are highlighted. Tissue engineering hybrid constructions with enhanced bone regeneration ability, such as cell-based or growth factor-based bone substitutes, are discussed as an emerging area of development.

Indexed as

DentistryBone SubstitutesBone TransplantationCell SurvivalHumansIntercellular Signaling Peptides and ProteinsOsteogenesisBone SubstitutesIntercellular Signaling Peptides and Proteinsbone defectsbone graftbone reconstructionbone tissue engineeringdental implantnatural and synthetic bone substitutesreplacing tooth loss

Identifiers

PMID34070157
PMCPMC8158510
OpenAlexW3163747386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.