Evidence map›Paper›PMID 34070140›Full record

ArticleMolecules (Basel, Switzerland)2021

Prioritisation of Compounds for 3CL

Marko Jukič, Blaž Škrlj, Gašper Tomšič, Sebastian Pleško, Črtomir Podlipnik, Urban Bren

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  6. Review
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  9. Article
  10. Investigating novel thiazolyl-indazole derivatives as scaffolds for SARS-CoV-2 MEuropean journal of medicinal chemistry reports · 2022
    Article
  11. Artificial Intelligence Technologies for COVID-19 De Novo Drug Design.International journal of molecular sciences · 2022
    Review
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Marko JukičLaboratory of Physical Chemistry and Chemical Thermodynamics, Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova ulica 17, SI-2000 Maribor, Slovenia.ORCID 0000-0001-6083-5024
Blaž ŠkrljInstitute Jožef Stefan, Jamova cesta 39, SI-1000 Ljubljana, Slovenia.ORCID 0000-0002-9916-8756
Gašper TomšičIndependent Researcher, Cesta Cirila Kosmača 66, SI-1000 Ljubljana, Slovenia.
Sebastian PleškoErudio, Litostrojska Cesta 40, SI-1000 Ljubljana, Slovenia.
Črtomir PodlipnikFaculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000 Ljubljana, Slovenia.ORCID 0000-0002-8429-0273
Urban BrenLaboratory of Physical Chemistry and Chemical Thermodynamics, Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova ulica 17, SI-2000 Maribor, Slovenia.
University of Primorska · SIJožef Stefan Institute · SILitostroj Power (Slovenia) · SIUniversity of Ljubljana · SI

Funding

Slovenian Ministry of Science and Education HPC-RIVRSlovenian Research Agency (ARRS) J1-2471Slovenian Research Agency (ARRS) P1-0201Slovenian Research Agency (ARRS) P2-0046Slovenian Research Agency (ARRS) P2-0103Slovenian Research Agency (ARRS) P6-0411
6 · The paper itself

Abstract

COVID-19 represents a new potentially life-threatening illness caused by severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2 pathogen. In 2021, new variants of the virus with multiple key mutations have emerged, such as B.1.1.7, B.1.351, P.1 and B.1.617, and are threatening to render available vaccines or potential drugs ineffective. In this regard, we highlight 3CL

Indexed as

Coronavirus 3C ProteasesSmall Molecule LibrariesAntiviral AgentsCysteine Proteinase InhibitorsHumansSARS-CoV-23C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesCysteine Proteinase InhibitorsSmall Molecule Libraries3C-like protease3CLprochemical library designcompound prioritisationCOVID-19high-throughputinhibitorsin silico drug designmachine learningMproSARS-CoV-2virtual screening

Identifiers

PMID34070140
PMCPMC8158358
OpenAlexW3161715779

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.