ArticleAntioxidants (Basel, Switzerland)2021
The Pro-Oxidant Activity of Red Wine Polyphenols Induces an Adaptive Antioxidant Response in Human Erythrocytes.
Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Phytochemicals Possess Selective Chemopreventive Mechanisms That Safeguard Human Cells from Oxidative Toxicity.Biomolecules · 2026Article
- Antioxidant Potential and Volatile Aroma Profiling of Red Wines from the Tarnave Vineyard.Molecules (Basel, Switzerland) · 2025Article
- Integrated Assessment of Silver Nanoparticles on Plant Growth and Cytogenotoxicity UsingJournal of xenobiotics · 2025Article
- Antioxidant potential of wine polyphenols on hematological indices and apical periodontitis in male rats.Journal of applied oral science : revista FOB · 2025Article
- Enhancing wine shelf-life: Insights into factors influencing oxidation and preservation.Heliyon · 2024Review
- Red Wine and Sexual Function in Men: An Original Point of View.Journal of clinical medicine · 2023Article
- Curcumin treatment enhances bioactive metabolite accumulation and reduces enzymatic browning in soybean sprouts during storage.Food chemistry: X · 2023Article
- Beneficial Effects of Red Wine Polyphenols on Human Health: Comprehensive Review.Current issues in molecular biology · 2023Review
- Review
- Protective Effects of Wine Polyphenols on Oxidative Stress and Hepatotoxicity Induced by Acrylamide in Rats.Antioxidants (Basel, Switzerland) · 2022Article
- Impact of the Acetaldehyde-Mediated Condensation on the Phenolic Composition and Antioxidant Activity ofMolecules (Basel, Switzerland) · 2022Article
- Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action.Frontiers in pharmacology · 2022Review
- "Good Wine Makes Good Blood": An Integrated Approach to Characterize Autochthonous Apulian Grapevines as Promising Candidates for Healthy Wines.International journal of biological sciences · 2022Article
- In Vitro and In Silico Interaction Studies with Red Wine Polyphenols against Different Proteins from Human Serum.Molecules (Basel, Switzerland) · 2021Article
- Cellular Defensive Mechanisms of Tea Polyphenols: Structure-Activity Relationship.International journal of molecular sciences · 2021Review
- From Fighting Critters to Saving Lives: Polyphenols in Plant Defense and Human Health.International journal of molecular sciences · 2021Review
- Antioxidant/Pro-Oxidant Actions of Polyphenols From Grapevine and Wine By-Products-Base for Complementary Therapy in Ischemic Heart Diseases.Frontiers in cardiovascular medicine · 2021Review
- Research Progress on Dietary Intervention in Radiation Protection.Dose-response : a publication of International Hormesis SocietyReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The protective effect of dealcoholized red wine on human health has been partially associated with its polyphenolic components, suggesting that the pool of polyphenols, including flavonoids and anthocyanins, can be responsible for the functional effects of this beverage. We hypothesize a new role of red wine polyphenols (RWp) in modulating the antioxidant potential of erythrocytes, protecting them against oxidative stress. We previously demonstrated that RWp activated the Plasma Membrane Redox System (PMRS), which is involved in neutralizing plasma free radicals. Here, we investigated the underlying mechanism triggered by RWp in the activation of PMRS via the involvement of GSH. Hence, treatment of human erythrocytes with RWp (73 μg/mL Gallic Acid Equivalents) increased GSH intracellular concentration, which depends upon the activation of glutathione reductase (GR) and glucose-6-phosphate dehydrogenase (G6PD), whose enzymatic activities increase of about 30% and 47%, respectively. Changes in the GSH pathway induced by RWp were associated with a slight but significant increase in reactive oxygen species (ROS). We conclude that the pro-oxidant effect of RWp promoted an adaptive stress response in human erythrocytes, which enhances their antioxidant defense.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.