Evidence map›Paper›PMID 34070126›Full record

ArticleMolecules (Basel, Switzerland)2021

New O-Aryl-Carbamoyl-Oxymino-Fluorene Derivatives with MI-Crobicidal and Antibiofilm Activity Enhanced by Combination with Iron Oxide Nanoparticles.

Ilinca Margareta Vlad, Diana Camelia Nuță, Robert Viorel Ancuceanu, Miron Teodor Caproiou, Florea Dumitrascu, Ioana Cristina Marinas, Mariana Carmen Chifiriuc, Luminita Gabriela Măruţescu, Irina Zarafu, Ioana Raluca Papacocea and 5 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Design, Synthesis, and Biological Evaluation ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Ilinca Margareta VladDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6 Traian Vuia, 020956 Bucharest, Romania.
Diana Camelia NuțăDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6 Traian Vuia, 020956 Bucharest, Romania.ORCID 0000-0002-7685-3291
Robert Viorel AncuceanuDepartment of Pharmaceutical Botany, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6 Traian Vuia, 020956 Bucharest, Romania.
Miron Teodor CaproiouCostin D. Nenițescu" The Organic Chemistry Centre of Romanian Academy, 202B Splaiul Independenței, 060023 Bucharest, Romania.
Florea DumitrascuCostin D. Nenițescu" The Organic Chemistry Centre of Romanian Academy, 202B Splaiul Independenței, 060023 Bucharest, Romania.
Ioana Cristina MarinasDepartment of Microbiology, Faculty of Biology & Research Institute of the University of Bucharest (ICUB), University of Bucharest, 060101 Bucharest, Romania.ORCID 0000-0002-7342-5398
Mariana Carmen ChifiriucDepartment of Microbiology, Faculty of Biology & Research Institute of the University of Bucharest (ICUB), University of Bucharest, 060101 Bucharest, Romania.ORCID 0000-0001-6098-1857
Luminita Gabriela MăruţescuDepartment of Microbiology, Faculty of Biology & Research Institute of the University of Bucharest (ICUB), University of Bucharest, 060101 Bucharest, Romania.
Irina ZarafuDepartment of Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 4-12 Regina Elisabeta, 030018 Bucharest, Romania.ORCID 0000-0002-9144-5528
Ioana Raluca PapacoceaDepartment of Physiology I, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 8 Eroilor Sanitari, 050474 Bucharest, Romania.
Bogdan Ștefan VasileFaculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, 313 Spl. Independentei, 060042 Bucharest, Romania.ORCID 0000-0002-2267-6453
Adrian Ionuț NicoarăFaculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, 313 Spl. Independentei, 060042 Bucharest, Romania.ORCID 0000-0002-4133-7377
Cornelia-Ioana IlieFaculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, 313 Spl. Independentei, 060042 Bucharest, Romania.ORCID 0000-0002-5504-5156
Anton FicaiAcademy of Romanian Scientists, 3 Ilfov Street, 050045 Bucharest, Romania.ORCID 0000-0002-1777-0525
Carmen LimbanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6 Traian Vuia, 020956 Bucharest, Romania.
Carol Davila University of Medicine and Pharmacy · ROUniversity of Bucharest · ROUniversitatea Națională de Știință și Tehnologie Politehnica București · RORomanian Academy · ROAcademia Oamenilor de Știință din România · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance is one of the major public health threats at the global level, urging the search for new antimicrobial molecules. The fluorene nucleus is a component of different bioactive compounds, exhibiting diverse pharmacological actions. The present work describes the synthesis, chemical structure elucidation, and bioactivity of new O-aryl-carbamoyl-oxymino-fluorene derivatives and the contribution of iron oxide nanoparticles to enhance the desired biological activity. The antimicrobial activity assessed against three bacterial and fungal strains, in suspension and biofilm growth state, using a quantitative assay, revealed that the nature of substituents on the aryl moiety are determinant for both the spectrum and intensity of the inhibitory effect. The electron-withdrawing inductive effect of chlorine atoms enhanced the activity against planktonic and adhered

Indexed as

Anti-Infective AgentsBacteriaBacterial AdhesionBiofilmsCarbon-13 Magnetic Resonance SpectroscopyFluorenesFungiMagnetic Iron Oxide NanoparticlesMagnetometryMicrobial Sensitivity TestsPlanktonProton Magnetic Resonance SpectroscopySpectroscopy, Fourier Transform InfraredAnti-Infective AgentsFluorenes9-fluorenone9H-fluoren-9-one oximeantibiofilmantimicrobialiron oxide nanoparticlesO-aryl-carbamoyl-oxymino-fluorene derivatives

Identifiers

PMID34070126
PMCPMC8158365
OpenAlexW3163835631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.